Actinium-225 as an example for monitoring of internal exposure of occupational intakes of radionuclides in face of new nuclear-medical applications for short-lived alpha emitting particles

• Published in: Radiation and environmental biophysics 2024-08, Vol.63 (3), p.385-394
• Main Authors: Hartmann, Sven, Taubner, Kerstin, Vogt, Tobias, Meisenberg, Oliver, Schkade, Uwe-Karsten, Steyer, Christian, Meckel, Marian, Kesenheimer, Christian
• Format: Article
• Language: English
• Subjects: Actinium; Adult; Alpha Particles; Alpha rays; Biological and Medical Physics; Biophysics; Ecosystems; Effects of Radiation/Radiation Protection; Environmental Physics; Exposure; Humans; Male; Monitoring; Monitoring/Environmental Analysis; Nuclear Medicine; Occupational exposure; Occupational Exposure - analysis; Physics; Physics and Astronomy; Radiation; Radiation Dosage; Radiation Exposure; Radiation measurement; Radiation Monitoring - methods; Radiation Protection; Radioisotopes; Radioisotopes - urine; Scientific imaging; Scintillation counters; Solid Phase Extraction; Solid phases; Spectrometry; α Radiation
• ISSN: 0301-634X; 1432-2099; 1432-2099
• DOI: 10.1007/s00411-024-01081-4

Monitoring of internal exposure to short-lived alpha-emitting radionuclides such as actinium-225 ( 225 Ac), which are becoming increasingly important in nuclear medicine, plays an important role in the radiation protection of occupationally exposed persons. After having tested gamma spectrometry, liquid scintillation counting and alpha spectrometry for monitoring of internal exposure, the focus of the present study was on solid phase extraction of 225 Ac from urine in combination with alpha spectrometry. The development of the method was based on recent findings from the literature on this topic. The method was used in a pilot phase to monitor internal exposure of four workers who were directly or indirectly involved in the manufacture and/or use of 225 Ac. The monitoring protocol allowed a relatively short 24-hour urine sample analysis with excellent recovery of the internal standard, but it did not allow for a detection limit of less than 1 mBq nor a sufficient yield of 225 Ac. Based on these results it is concluded that an in vitro excretion analysis alone is not appropriate for monitoring internal exposure to 225 Ac. Instead, different radiation monitoring techniques have to be combined to ensure the radiation protection of employees.