Characteristics of Stroke-related Seizures and their Predictive Factors: A Tertiary Care Center Experience

• Published in: Annals of African medicine 2024-07, Vol.23 (3), p.285-290
• Main Authors: Shariff, Erum, Nazish, Saima, Zafar, Azra, Shahid, Rizwana, Aljaafari, Danah, Soltan, Nehad Mahmoud, Farhan, Ahmed Mohamed, Alkhamis, Fahd A, AlShurem, Mohammed, Basheir, Osama Faisal Hassan, Alshamrani, Foziah, Albakr, Aishah Ibrahim, Al Ghamdi, Omar, AlSulaiman, Abdulla A, Al Abdali, Majed
• Format: Article
• Language: English
• Subjects: Adult; Aged; Atherosclerosis; Blood; Cardiac patients; Female; Heart diseases; Humans; Levetiracetam; Male; Medical examination; Medical records; Medical research; Medicine, Experimental; Middle Aged; Retrospective Studies; Risk Factors; Seizures (Medicine); Seizures - epidemiology; Seizures - etiology; Severity of Illness Index; Stroke; Stroke (Disease); Stroke - complications; Stroke - epidemiology; Tertiary Care Centers - statistics & numerical data
• ISSN: 1596-3519; 0975-5764; 0975-5764
• DOI: 10.4103/aam.aam_15_23

Various risk factors have been described in the literature that increase the risk of seizures associated with stroke. This study was aimed to determine the occurrence rate of poststroke seizures (PSSs) and the associated risk factors in Arab population. Study included all stroke patients aged >18 years with a minimum follow-up of 24 months following stroke to identify seizure occurrence. Patient's hospital records for all admissions and clinic visits were reviewed. Seizures were classified into early PSS if they occur within 1 week of stroke, and late PSS if they occur after 1 week of stroke. Out of 594 patients, 380 were males. Seizure occurrence was higher in anterior circulation infarctions (94.8%, P < 0.05), cortical location (80.5%, P < 0.05), large artery atherosclerosis (63.8%, P < 0.05), lower activated partial thromboplastin time (APTT) (P = 0.0007), patients with ischemic heart disease (IHD) (P = 0.01), and those who underwent craniotomy (P = 0.001). Nonhigh-density lipoprotein cholesterol was inversely related to PSS (P = 0.01). Higher stroke severity (89%) and confusion (67%) at the time of presentation were independently related to PSS. Eighty-two (13.8%) patients had PSS. Greater stroke severity at presentation with altered sensorium was independent risk factors for the development of PSS. Patients with underlying IHD, lower APTT, and undergoing neurosurgical intervention require vigilant monitoring for PSS.