Laponite nanoclays for the sustained delivery of therapeutic proteins

Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as a promising candidate for their sustained delivery. Despite its unique properties allow to...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2024-10, Vol.201, p.106858, Article 106858
Main Authors: Gonzalez-Pujana, Ainhoa, Igartua, Manoli, Hernandez, Rosa Maria, Santos-Vizcaino, Edorta
Format: Article
Language:English
Subjects:
Animals
Clay - chemistry
Delayed-Action Preparations
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems - methods
Drug Liberation
Humans
Hydrogel
Hydrogels - chemistry
Hydrogen-Ion Concentration
Laponite
Nanoclay
Nanocomposites - chemistry
Protein
Proteins - administration & dosage
Proteins - chemistry
Silicates - chemistry
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Summary:Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as a promising candidate for their sustained delivery. Despite its unique properties allow to load and release proteins mitigating burst release and extending their effects, precise control over Laponite-protein interactions remains challenging since it depends on a complex interplay of factors whose implication is not fully understood yet. The aim of this review article is to shed light on this issue, providing a comprehensive discussion of the factors influencing protein loading and release, including the physicochemical properties of the nanoclay and proteins, pH, dispersion buffer, clay/protein concentration and Laponite degradation. Furthermore, we thoroughly revise the array of bioactive proteins that have been delivered from formulations containing the nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, a promising avenue currently under extensive investigation. [Display omitted]
ISSN:0928-0987
1879-0720
1879-0720
DOI:10.1016/j.ejps.2024.106858