Hair follicle sulfotransferase activity and effectiveness of oral minoxidil in androgenetic alopecia

• Published in: Journal of cosmetic dermatology 2024-11, Vol.23 (11), p.3767-3773
• Main Authors: Jimenez‐Cauhe, Juan, Vaño‐Galvan, Sergio, Mehta, Nina, Hermosa‐Gelbard, Angela, Ortega‐Quijano, Daniel, Buendia‐Castaño, Diego, Fernández‐Nieto, Diego, Porriño‐Bustamante, Maria, Saceda‐Corralo, David, Pindado‐Ortega, Cristina, Moreno‐Arrones, Oscar M., Wambier, Carlos, Dhura, Rachita, Lotti, Torello, Goren, Andy
• Format: Article
• Language: English
• Subjects: androgenetic alopecia; enzyme activity; hair follicle; minoxidil; sulfotransferase (SULT1A1)
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.16473

Background Androgenetic alopecia (AGA) is common. While topical minoxidil remains the only FDA‐approved therapeutic for AGA, its efficacy is limited in stimulating clinically significant hair regrowth over the longer term. Oral minoxidil, which is used off‐label, is a promising alternative; however, its effectiveness and underlying mechanisms warrant further investigation. Aims To elucidate the site of action and infer the physiological mechanisms underlying therapeutic responses to oral minoxidil in patients with AGA. Methods Forty‐one patients with AGA underwent 6 months of low‐dose oral minoxidil treatment. Minoxidil sulfotransferase (SULT) activity was assayed in plucked scalp hair follicles. The primary outcome was hair growth after low‐dose oral minoxidil treatment for a minimum of 6 months, and the secondary outcome was SULT activity in hair follicles. Results After 6 months of treatment, 26 (63.4%) patients experienced a clinical improvement in alopecia symptoms. The response rate was higher in men (19/26 [73.1%]) than in women (6/15 [40.0%]). Patients with low hair follicle SULT activity demonstrated a higher minoxidil response rate than those with high enzyme activity (85% vs. 43%, p = 0.009). Conclusions Our findings indicate that low SULT activity within the hair follicles is associated with a favorable response to oral minoxidil therapy in patients with AGA. Further elucidation of the underlying mechanisms could significantly improve personalized therapeutic approaches through improved patient selection and the rational design of adjuvant treatments.