Pharmacogenetics of therapies in rheumatoid arthritis: An update

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory arthritis. Despite many treatment advances, achieving remission or low-disease activity in RA remains challenging, often requiring trial and error approaches with numerous medications. Precision medicine, particularly pharmacogenomics,...

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Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2024-12, Vol.38 (4), p.101974, Article 101974
Main Authors: Babiker-Mohamed, Mohamed H., Bhandari, Sambhawana, Ranganathan, Prabha
Format: Article
Language:English
Subjects:
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Biologics
DMARDs
Humans
Liver-Specific Organic Anion Transporter 1 - genetics
Methyltransferases - genetics
Pharmacogenetics
Polymorphism, Single Nucleotide
Precision Medicine
Rheumatoid arthritis
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Summary:Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory arthritis. Despite many treatment advances, achieving remission or low-disease activity in RA remains challenging, often requiring trial and error approaches with numerous medications. Precision medicine, particularly pharmacogenomics, explores how genetic factors influence drug response in individual patients, and incorporates such factors to develop personalized treatments for individual patients. Genetic variations in drug-metabolizing enzymes, transporters, and targets may contribute to inter-individual differences in drug efficacy and toxicity. Advancements in molecular sequencing have allowed rapid identification of such variants, including single nucleotide polymorphisms (SNPs). This review highlights recent major findings in the pharmacogenetics of therapies in RA, focusing on key genes and SNPs to provide insights into current trends and developments in this field.
ISSN:1521-6942
1532-1770
1532-1770
DOI:10.1016/j.berh.2024.101974