Clinical Importance of Focal Adhesion Kinase (FAK)-Src and Paxillin Expression in Renal Cell Carcinoma

The complex focal adhesion kinase (FAK)/Src and paxillin seem to play a key role in the pathogenesis and progression of cancer. The aim of this study is to evaluate the expression of these proteins in renal cell carcinomas (RCCs), considering the immunoreactive score (IRS), the positivity and the in...

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Published in:Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e62706
Main Authors: Mitsos, Panagiotis, Anastasiou, Ioannis, Constantinides, Constantinos, Deligiannis, Dimitrios, Katafigiotis, Ioannis, Papakonstantinou, Anna, Tzotzola, Vasiliki, Mitropoulos, Dionysios, Theocharis, Stamatios
Format: Article
Language:English
Subjects:
Biotechnology
Cancer therapies
Females
Gender
Kidney cancer
Kinases
Medical prognosis
Metastasis
Tumors
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Summary:The complex focal adhesion kinase (FAK)/Src and paxillin seem to play a key role in the pathogenesis and progression of cancer. The aim of this study is to evaluate the expression of these proteins in renal cell carcinomas (RCCs), considering the immunoreactive score (IRS), the positivity and the intensity, and to find any association with patients' clinical characteristics, histologic type and other pathological features that imply a possible pathophysiological or prognostic role of FAK/Src and paxillin in RCC. Patients with RCC who had undergone partial or radical nephrectomy from January 2009 to September 2010 were eligible for this retrospective cross-sectional study. The immunohistochemical expression of FAK, Src and paxillin proteins in formalin-fixed paraffin-embedded tumour tissue was analysed in association with various clinicopathological features. Out of ninety patients, 58 had clear cell renal carcinoma, 15 had papillary, 11 had chromophobe and six had unclassified RCC. FAK, Src and paxillin were expressed in 55.6%, 32.2% and 18.9% of all cases, respectively. In univariate analysis, FAK positivity and IRS were more likely in patients with papillary and chromophobe histologic type versus clear cell RCC (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.62706