One flask cascade approach to a complex pyrano2,3-cpyrazole-pyrazolone hybrid heterocyclic system and its initiatory neurobiological profiling

A one-pot multicomponent approach towards a hybrid heterocyclic pyrano[2,3-c]pyrazole-pyrazolone framework involving tandem Knoevenagel condensation, sequential intermolecular 1,6-Michael addition, and 6-endo dig cyclization between diynones and pyrazolones, mediated by DBU, has been discovered. Thi...

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Published in:Chemical communications (Cambridge, England) England), 2024-08, Vol.60 (64), p.8443
Main Authors: Balasubramani, Alagesan, Sudarshana, K A, Kushwaha, Roli, Chakravarty, Sumana, Pabbaraja, Srihari, Mehta, Goverdhan
Format: Article
Language:English
Online Access:Get full text
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Summary:A one-pot multicomponent approach towards a hybrid heterocyclic pyrano[2,3-c]pyrazole-pyrazolone framework involving tandem Knoevenagel condensation, sequential intermolecular 1,6-Michael addition, and 6-endo dig cyclization between diynones and pyrazolones, mediated by DBU, has been discovered. This process embodies several green and sustainable chemistry features. Preliminary bioactivity profiling of the new chemical entities indicates neuroprotective and AChE inhibitory activities.A one-pot multicomponent approach towards a hybrid heterocyclic pyrano[2,3-c]pyrazole-pyrazolone framework involving tandem Knoevenagel condensation, sequential intermolecular 1,6-Michael addition, and 6-endo dig cyclization between diynones and pyrazolones, mediated by DBU, has been discovered. This process embodies several green and sustainable chemistry features. Preliminary bioactivity profiling of the new chemical entities indicates neuroprotective and AChE inhibitory activities.
ISSN:1364-548X
1364-548X
DOI:10.1039/d4cc02813a