The need for novel approaches to HIV-1 vaccine development

The study enrolled 2636 women aged 18–35 years without HIV-1 or HIV-2 from multiple hospital sites in sub-Saharan Africa between 2017 and 2019. [...]over the past decade, the field has started to work on a so-called rational approach to HIV-1 vaccine design. Despite the multitude of promising approa...

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Bibliographic Details
Published in:The Lancet infectious diseases 2024-11, Vol.24 (11), p.1178-1179
Main Authors: Lehmann, Clara, Schommers, Philipp
Format: Article
Language:English
Subjects:
Antibodies
HIV
Human immunodeficiency virus
Infections
Prevention
Vaccine development
Vaccines
Viral infections
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Summary:The study enrolled 2636 women aged 18–35 years without HIV-1 or HIV-2 from multiple hospital sites in sub-Saharan Africa between 2017 and 2019. [...]over the past decade, the field has started to work on a so-called rational approach to HIV-1 vaccine design. Despite the multitude of promising approaches, the induction of high and protective titers of one or more broadly neutralising antibodies will most probably need a whole set of immunogens administered over an extended period (figure). [...]it is imperative that the HIV vaccine development field convinces shareholders and funding agencies that studies such as the Imbokodo trial do not mark the end of the search for an HIV-1 vaccine.
ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(24)00398-0