Different levels and clinical significance of growth differentiation factor-15 in patients with atrial fibrillation

To measure the concentration of growth differentiation factor-15 (GDF-15) in the serum of patients with atrial fibrillation (AF), to study the correlations between the levels of GDF-15 and different factors including basic clinical information, biochemical examinations, and atrial structure, and fur...

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Bibliographic Details
Published in:Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2024-08, Vol.56 (4), p.715
Main Authors: Wei, Ying, Cui, Ming, Liu, Shuwang, Yu, Haiyi, Gao, Wei, Li, Lei
Format: Article
Language:Chinese
Subjects:
Aged
Atrial Fibrillation - blood
Clinical Relevance
Female
Growth Differentiation Factor 15 - blood
Humans
Male
Middle Aged
Prospective Studies
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Summary:To measure the concentration of growth differentiation factor-15 (GDF-15) in the serum of patients with atrial fibrillation (AF), to study the correlations between the levels of GDF-15 and different factors including basic clinical information, biochemical examinations, and atrial structure, and further to explore the association between GDF-15 and AF types and structural remodeling. AF patients who were admitted to the ward of the Department of Cardiology at Peking University Third Hospital between October 2017 and October 2019 were prospectively enrolled. Patients admitted to the ward at the same time with sinus rhythm and no prior AF history were enrolled in the control group. Clinical information and blood samples of the patients were collected. Enzyme-linked immunosorbent assay was used to measure the concentration of GDF-15. SPSS 23.0 was used for statistical analysis. In the study, 156 AF patients (64 persistent AF and 92 paroxysmal AF) and 38 patients of the control group were included. Serum GDF-15 l
ISSN:1671-167X