Linking homocysteine and ferroptosis in cardiovascular disease: insights and implications

Homocysteine (Hcy) is a metabolic intermediate product derived from methionine. Hyperhomocysteinemia is a condition associated with various diseases. Hcy is recognized as a risk factor for cardiovascular disease (CVD). Ferroptosis, a novel form of cell death, is primarily characterized by substantia...

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Bibliographic Details
Published in:Apoptosis (London) 2024-12, Vol.29 (11-12), p.1944-1958
Main Authors: Li, Xiaozhong, Zhou, Zheng, Tao, Yu, He, Lei, Zhan, Fenfang, Li, Juxiang
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Atherosclerosis
B cells
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cell Biology
Cell death
Development and progression
Diabetes
Enzymes
Ferroptosis
Heart diseases
Homocysteine
Homocysteine - metabolism
Humans
Hydrogen sulfide
Hyperhomocysteinemia
Hyperhomocysteinemia - metabolism
Hyperhomocysteinemia - pathology
Impact analysis
Iron - metabolism
Lipid Peroxidation
Lipids
Medical research
Medicine, Experimental
Metabolism
Methionine
Morphology
Mutation
Nervous system diseases
Neurological diseases
Oncology
Oxidative stress
Peroxidation
Review
Risk factors
Virology
Citations: Items that this one cites
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Description
Summary:Homocysteine (Hcy) is a metabolic intermediate product derived from methionine. Hyperhomocysteinemia is a condition associated with various diseases. Hcy is recognized as a risk factor for cardiovascular disease (CVD). Ferroptosis, a novel form of cell death, is primarily characterized by substantial iron accumulation and lipid peroxidation. Recent research indicates a close association between ferroptosis and the pathophysiological processes of tumors, neurological diseases, CVD, and other ailments. However, limited research has been conducted on the impact of Hcy on ferroptosis. Therefore, this paper aimed to investigate the potential roles and mechanisms of homocysteine and ferroptosis in the context of cardiovascular disease. By conducting comprehensive literature research and analysis, we aimed to summarize recent advancements in understanding the effects of homocysteine on ferroptosis in cardiovascular diseases. This research contributes to a profound understanding of this critical domain.
ISSN:1360-8185
1573-675X
1573-675X
DOI:10.1007/s10495-024-01999-6