Leptin is a potential biomarker of childhood obesity and an indicator of the effectiveness of weight‐loss interventions

Summary Childhood obesity represents a significant public health concern, imposing a substantial burden on the healthcare system. Furthermore, weight‐loss programs often exhibit reduced effectiveness in adults who have a history of childhood obesity. Therefore, early intervention against childhood o...

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Published in:Obesity reviews 2024-11, Vol.25 (11), p.e13807-n/a
Main Authors: Al Zein, Mohammad, Akomolafe, Aishat Funmilayo, Mahmood, Fathima R., Khrayzat, Ali, Sahebkar, Amirhossein, Pintus, Gianfranco, Kobeissy, Firas, Eid, Ali H.
Format: Article
Language:English
Subjects:
Adipocytes
adipokines
Biomarkers
Biomarkers - blood
BMI
Body Mass Index
Body size
Body weight loss
Child
Children
Effectiveness
Humans
Leptin
Leptin - blood
metabolic disease
Obesity
Pediatric Obesity - blood
Pediatric Obesity - therapy
Public health
Satiety
Weight Loss
Weight Reduction Programs - methods
weight regain
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Summary:Summary Childhood obesity represents a significant public health concern, imposing a substantial burden on the healthcare system. Furthermore, weight‐loss programs often exhibit reduced effectiveness in adults who have a history of childhood obesity. Therefore, early intervention against childhood obesity is imperative. Presently, the primary method for diagnosing childhood obesity relies on body mass index (BMI), yet this approach has inherent limitations. Leptin, a satiety hormone produced by adipocytes, holds promise as a superior tool for predicting both childhood and subsequent adulthood obesity. In this review, we elucidate the tools employed for assessing obesity in children, delve into the biological functions of leptin, and examine the factors governing its expression. Additionally, we discuss maternal and infantile leptin levels as predictors of childhood obesity. By exploring the relationship between leptin levels and weight loss, we present leptin as a potential indicator of the effectiveness of obesity interventions.
ISSN:1467-7881
1467-789X
1467-789X
DOI:10.1111/obr.13807