N -Alkylation of amines with primary/secondary alcohols using a novel cobalt(II) inverse triazolyl-pyridine complex

Herein, we report a highly effective homogeneous methodology for the -alkylation of amines with primary and secondary alcohols using a Co(II)-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired -alkylated products in u...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-08, Vol.60 (65), p.8581-8584
Main Authors: Shekhawat, Bhawana, Gahlaut, Puneet Singh, Gautam, Deepak, Jana, Barun
Format: Article
Language:English
Subjects:
Alcohols
Alkylation
Amines
Cobalt
Functional groups
Methodology
Pyridines
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Summary:Herein, we report a highly effective homogeneous methodology for the -alkylation of amines with primary and secondary alcohols using a Co(II)-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired -alkylated products in up to 98% yield. A number of control experiments establish that the developed methodology follows a hydrogen auto-transfer (HAT) pathway.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc01996b