Association of fatty liver index with sudden cardiac arrest in young adults

• Published in: Metabolism, clinical and experimental clinical and experimental, 2024-09, Vol.158, p.155981, Article 155981
• Main Authors: Jeong, Joo Hee, Kim, Yun Gi, Han, Kyung-Do, Roh, Seung-Young, Lee, Hyoung Seok, Choi, Yun Young, Yim, Sun Young, Shim, Jaemin, Kim, Young-Hoon, Choi, Jong-Il
• Format: Article
• Language: English
• Subjects: Adult; Body Mass Index; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - etiology; Fatty Liver - complications; Fatty Liver - epidemiology; Fatty liver index; Female; Humans; Male; Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty liver disease; Republic of Korea - epidemiology; Risk Factors; Sudden cardiac arrest; Triglycerides - blood; Young Adult
• ISSN: 0026-0495; 1532-8600; 1532-8600
• DOI: 10.1016/j.metabol.2024.155981

Metabolic dysfunction-associated steatotic liver disease (MASLD) contributes to cardiovascular events. Therefore, we aimed to identify the association of MASLD, as indicated by the fatty liver index (FLI), on sudden cardiac arrest (SCA) in young adults. We analyzed data from adults aged 20–39 years, who underwent health examinations between 2009 and 2012, sourced from the Korean National Health Insurance Service database. The presence of MASLD was determined using the FLI, which was calculated based on an individual's body mass index, waist circumference, gamma-glutamyl transferase and triglyceride levels. The primary outcome was the occurrence of SCA during the follow-up period, until December 2020. Of the total 5,398,082 individuals analyzed, 4,021,056 (74.5 %) had a normal FLI (FLI