Maternal hemoglobin and iron status in early pregnancy and childhood cardiac outcomes

Dysregulation of iron homeostasis is associated with cardiac alterations in a sex-dependent manner in adults. It is unknown whether iron status during pregnancy has long-term impact on cardiovascular health, and if this association is influenced by sex. Therefore, this study aimed to evaluate sex-sp...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2024-09, Vol.43 (9), p.1997-2004
Main Authors: Quezada-Pinedo, Hugo G., Jaddoe, Vincent, Gaillard, Romy, Duijts, Liesbeth, van Rijn, Bas, Reiss, Irwin K.M., Vermeulen, Marijn J., Santos, Susana
Format: Article
Language:English
Subjects:
Adult
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - complications
Cardiac outcomes
Child
Children
Cohort Studies
Female
Ferritins - blood
Fetal programming
Heart - physiopathology
Hemoglobins - analysis
Humans
Iron - blood
Iron depletion
Iron excess
Male
Maternal Nutritional Physiological Phenomena
Nutritional Status
Pregnancy - blood
Sex Characteristics
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Summary:Dysregulation of iron homeostasis is associated with cardiac alterations in a sex-dependent manner in adults. It is unknown whether iron status during pregnancy has long-term impact on cardiovascular health, and if this association is influenced by sex. Therefore, this study aimed to evaluate sex-specific association between maternal iron status during early pregnancy and cardiac outcomes in children aged 10 years. In a population-based cohort study among 1972 mother–child pairs, hemoglobin and ferritin were measured in early pregnancy (
ISSN:0261-5614
1532-1983
1532-1983
DOI:10.1016/j.clnu.2024.07.009