The challenge of antimicrobial resistance (AMR): current status and future prospects

Antimicrobial resistance (AMR) represents a critical global threat, compromising the effectiveness of antibacterial drugs as bacteria adapt and survive exposure to many classes of these drugs. This phenomenon is primarily fueled by the widespread overuse and misuse of antibacterial drugs, exerting s...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2024-12, Vol.397 (12), p.9603-9615
Main Authors: Ferrara, Francesco, Castagna, Tommaso, Pantolini, Beatrice, Campanardi, Maria Chiara, Roperti, Martina, Grotto, Alessandra, Fattori, Martina, Dal Maso, Lucia, Carrara, Federica, Zambarbieri, Giulia, Zovi, Andrea, Capuozzo, Maurizio, Langella, Roberto
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antimicrobial agents
Antimicrobial resistance
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Biomedical and Life Sciences
Biomedicine
Drug development
Drug resistance
Drug Resistance, Bacterial
Epidemiology
Humans
Italy
Neurosciences
Pharmacology/Toxicology
Public health
Review
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Summary:Antimicrobial resistance (AMR) represents a critical global threat, compromising the effectiveness of antibacterial drugs as bacteria adapt and survive exposure to many classes of these drugs. This phenomenon is primarily fueled by the widespread overuse and misuse of antibacterial drugs, exerting selective pressure on bacteria and promoting the emergence of multi-resistant strains. AMR poses a top-priority challenge to public health due to its widespread epidemiological and economic implications, exacerbated not only by the diminishing effectiveness of currently available antimicrobial agents but also by the limited development of genuinely effective new molecules. In addressing this issue, our research aimed to examine the scientific literature narrating the Italian situation in the common European context of combating AMR. We sought to delineate the current state of AMR and explore future prospects through an analysis of strategies to counter antibacterial drug resistance. Adopting the “One Health” model, our objective was to comprehensively engage diverse sectors, integrate various disciplines, and propose programs, policies, and regulations. This narrative review, based on PubMed research related to antibiotic resistance, emphasizes the urgent need for a coordinated and proactive approach at both national and European levels to mitigate the impact of AMR and pave the way for effective strategies to counter this global health challenge.
ISSN:0028-1298
1432-1912
1432-1912
DOI:10.1007/s00210-024-03318-x