Undobolins A–L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus

Twelve previously undescribed ophiobolin-type sesterterpenoids, undobolins A–L (1–12), were isolated from Aspergillus undulatus, and their structures were elucidated by spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction experiments. Compound 1 was the second example of 20...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2024-08, Vol.87 (8), p.1965-1974
Main Authors: Zheng, Yuyi, Li, Qin, Gu, Minglang, Liao, Hong, Liang, Yu, Liu, Fei, Li, Xiao-Nian, Sun, Weiguang, Chen, Chunmei, Zhang, Yonghui, Zhu, Hucheng
Format: Article
Language:English
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Summary:Twelve previously undescribed ophiobolin-type sesterterpenoids, undobolins A–L (1–12), were isolated from Aspergillus undulatus, and their structures were elucidated by spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction experiments. Compound 1 was the second example of 20-nor-ophiobolin reported, while compounds 2–6 were notable for oxygenation of C-2, and compound 6 showed significant inhibitory activity against ConA-induced T lymphocyte proliferation with an IC50 value of 2.3 μM, which suggests a promising new direction in the quest for immunosuppressive agents.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.4c00385