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Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial
Chronic diarrhea affects approximately 5% of the population. Opioids inhibit gastrointestinal motility, and opium tincture has shown anti-propulsive effects in healthy, but no controlled studies of its clinical efficacy exist. We aimed to investigate the anti-propulsive and central nervous system (C...
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| Published in: | Scandinavian journal of gastroenterology 2024-09, Vol.59 (9), p.1023-1034 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 1034 |
| container_issue | 9 |
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| container_title | Scandinavian journal of gastroenterology |
| container_volume | 59 |
| creator | Okdahl, Tina Høyer, Katrine Lundby Knoph, Cecilie Siggaard Davidsen, Line Larsen, Isabelle Myriam Mark, Esben Bolvig Hvas, Christian Lodberg Krogh, Klaus Drewes, Asbjørn Mohr |
| description | Chronic diarrhea affects approximately 5% of the population. Opioids inhibit gastrointestinal motility, and opium tincture has shown anti-propulsive effects in healthy, but no controlled studies of its clinical efficacy exist. We aimed to investigate the anti-propulsive and central nervous system (CNS) effects of opium tincture in patients with chronic diarrhea.
The study was a randomized, double-blinded, placebo-controlled, cross-over trial in subjects with chronic diarrhea refractory to standard treatment. Participants received opium tincture or placebo during two intervention periods, each lasting seven days. Bowel movements were recorded daily, and gastrointestinal transit time was investigated with the wireless motility capsule system. Gastrointestinal symptoms, health-related quality of life, and CNS effects (pupil size, reaction time, memory, and general cognition) were also investigated, along with signs of addiction.
Eleven subjects (mean age: 45 ± 17 years, 46% males) with a median of 4.7 daily bowel movements were included. The number of daily bowel movements was reduced during opium tincture treatment to 2.3 (
= 0.045), but not placebo (3.0,
= 0.09). Opium tincture prolonged the colonic transit time compared to placebo (17 h vs. 12 h,
|
| doi_str_mv | 10.1080/00365521.2024.2381694 |
| format | article |
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The study was a randomized, double-blinded, placebo-controlled, cross-over trial in subjects with chronic diarrhea refractory to standard treatment. Participants received opium tincture or placebo during two intervention periods, each lasting seven days. Bowel movements were recorded daily, and gastrointestinal transit time was investigated with the wireless motility capsule system. Gastrointestinal symptoms, health-related quality of life, and CNS effects (pupil size, reaction time, memory, and general cognition) were also investigated, along with signs of addiction.
Eleven subjects (mean age: 45 ± 17 years, 46% males) with a median of 4.7 daily bowel movements were included. The number of daily bowel movements was reduced during opium tincture treatment to 2.3 (
= 0.045), but not placebo (3.0,
= 0.09). Opium tincture prolonged the colonic transit time compared to placebo (17 h vs. 12 h,
< 0.001). In both treatment arms, there were no changes in self-reported gastrointestinal symptoms, health-related quality of life, or CNS effects, and no indication of addiction was present.
Opium tincture induced anti-propulsive effects in patients with chronic diarrhea refractory to standard treatment. This indicates that opium tincture is a relevant treatment strategy for selected patients with chronic diarrhea. Moreover, no evidence of opioid-induced sedation or addiction was found.
NCT05690321 (registered 2023-01-10).</description><identifier>ISSN: 0036-5521</identifier><identifier>ISSN: 1502-7708</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365521.2024.2381694</identifier><identifier>PMID: 39054596</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Analgesics, Opioid - therapeutic use ; Chronic Disease ; Cross-Over Studies ; Defecation - drug effects ; Diarrhea - drug therapy ; Double-Blind Method ; Female ; Gastrointestinal Motility - drug effects ; Gastrointestinal Transit - drug effects ; Humans ; Male ; Middle Aged ; Opium - therapeutic use ; Quality of Life ; Treatment Outcome</subject><ispartof>Scandinavian journal of gastroenterology, 2024-09, Vol.59 (9), p.1023-1034</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c234t-d64d8a3f822b20ff21bfce7f845cd3fa6bf687d8b523dc8c95abf5d8c8218e1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39054596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okdahl, Tina</creatorcontrib><creatorcontrib>Høyer, Katrine Lundby</creatorcontrib><creatorcontrib>Knoph, Cecilie Siggaard</creatorcontrib><creatorcontrib>Davidsen, Line</creatorcontrib><creatorcontrib>Larsen, Isabelle Myriam</creatorcontrib><creatorcontrib>Mark, Esben Bolvig</creatorcontrib><creatorcontrib>Hvas, Christian Lodberg</creatorcontrib><creatorcontrib>Krogh, Klaus</creatorcontrib><creatorcontrib>Drewes, Asbjørn Mohr</creatorcontrib><title>Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Chronic diarrhea affects approximately 5% of the population. Opioids inhibit gastrointestinal motility, and opium tincture has shown anti-propulsive effects in healthy, but no controlled studies of its clinical efficacy exist. We aimed to investigate the anti-propulsive and central nervous system (CNS) effects of opium tincture in patients with chronic diarrhea.
The study was a randomized, double-blinded, placebo-controlled, cross-over trial in subjects with chronic diarrhea refractory to standard treatment. Participants received opium tincture or placebo during two intervention periods, each lasting seven days. Bowel movements were recorded daily, and gastrointestinal transit time was investigated with the wireless motility capsule system. Gastrointestinal symptoms, health-related quality of life, and CNS effects (pupil size, reaction time, memory, and general cognition) were also investigated, along with signs of addiction.
Eleven subjects (mean age: 45 ± 17 years, 46% males) with a median of 4.7 daily bowel movements were included. The number of daily bowel movements was reduced during opium tincture treatment to 2.3 (
= 0.045), but not placebo (3.0,
= 0.09). Opium tincture prolonged the colonic transit time compared to placebo (17 h vs. 12 h,
< 0.001). In both treatment arms, there were no changes in self-reported gastrointestinal symptoms, health-related quality of life, or CNS effects, and no indication of addiction was present.
Opium tincture induced anti-propulsive effects in patients with chronic diarrhea refractory to standard treatment. This indicates that opium tincture is a relevant treatment strategy for selected patients with chronic diarrhea. Moreover, no evidence of opioid-induced sedation or addiction was found.
NCT05690321 (registered 2023-01-10).</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Chronic Disease</subject><subject>Cross-Over Studies</subject><subject>Defecation - drug effects</subject><subject>Diarrhea - drug therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal Transit - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Opium - therapeutic use</subject><subject>Quality of Life</subject><subject>Treatment Outcome</subject><issn>0036-5521</issn><issn>1502-7708</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9UclO5TAQtNAgeCyfMCMf50AeXhOHG0JsEhIXOEeO3dYzSuJgOyA48-Ek8ODUre6qXqoQ-kvJmhJFTgnhpZSMrhlhYs24omUtdtCKSsKKqiLqD1otmGIB7aODlJ4IIbIS9R7a5zWRQtblCn3cj37qcfaDyVMEvNEJ6yH7YoxhnLrkXwCDc2Bywn7Ao84ehjl_9XmDzSaGwRtsvY5xA_oMaxz1YEPv38Ge4LHTBtpQmDDkGLpuqc1tbGJIqQgvEHGOXndHaNfpLsHxNh6ix6vLh4ub4u7--vbi_K4wjItc2FJYpblTjLWMOMdo6wxUTglpLHe6bF2pKqtaybg1ytRSt05aZRSjCqjlh-j_99z5uecJUm56nwx0nR4gTKnhRImqErNgM1R-Q79ujeCaMfpex7eGkmYxoPkxoFkMaLYGzLx_2xVT24P9Zf0ozj8B6rGEJQ</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Okdahl, Tina</creator><creator>Høyer, Katrine Lundby</creator><creator>Knoph, Cecilie Siggaard</creator><creator>Davidsen, Line</creator><creator>Larsen, Isabelle Myriam</creator><creator>Mark, Esben Bolvig</creator><creator>Hvas, Christian Lodberg</creator><creator>Krogh, Klaus</creator><creator>Drewes, Asbjørn Mohr</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202409</creationdate><title>Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial</title><author>Okdahl, Tina ; Høyer, Katrine Lundby ; Knoph, Cecilie Siggaard ; Davidsen, Line ; Larsen, Isabelle Myriam ; Mark, Esben Bolvig ; Hvas, Christian Lodberg ; Krogh, Klaus ; Drewes, Asbjørn Mohr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-d64d8a3f822b20ff21bfce7f845cd3fa6bf687d8b523dc8c95abf5d8c8218e1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Chronic Disease</topic><topic>Cross-Over Studies</topic><topic>Defecation - drug effects</topic><topic>Diarrhea - drug therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Gastrointestinal Transit - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Opium - therapeutic use</topic><topic>Quality of Life</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okdahl, Tina</creatorcontrib><creatorcontrib>Høyer, Katrine Lundby</creatorcontrib><creatorcontrib>Knoph, Cecilie Siggaard</creatorcontrib><creatorcontrib>Davidsen, Line</creatorcontrib><creatorcontrib>Larsen, Isabelle Myriam</creatorcontrib><creatorcontrib>Mark, Esben Bolvig</creatorcontrib><creatorcontrib>Hvas, Christian Lodberg</creatorcontrib><creatorcontrib>Krogh, Klaus</creatorcontrib><creatorcontrib>Drewes, Asbjørn Mohr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okdahl, Tina</au><au>Høyer, Katrine Lundby</au><au>Knoph, Cecilie Siggaard</au><au>Davidsen, Line</au><au>Larsen, Isabelle Myriam</au><au>Mark, Esben Bolvig</au><au>Hvas, Christian Lodberg</au><au>Krogh, Klaus</au><au>Drewes, Asbjørn Mohr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>59</volume><issue>9</issue><spage>1023</spage><epage>1034</epage><pages>1023-1034</pages><issn>0036-5521</issn><issn>1502-7708</issn><eissn>1502-7708</eissn><abstract>Chronic diarrhea affects approximately 5% of the population. Opioids inhibit gastrointestinal motility, and opium tincture has shown anti-propulsive effects in healthy, but no controlled studies of its clinical efficacy exist. We aimed to investigate the anti-propulsive and central nervous system (CNS) effects of opium tincture in patients with chronic diarrhea.
The study was a randomized, double-blinded, placebo-controlled, cross-over trial in subjects with chronic diarrhea refractory to standard treatment. Participants received opium tincture or placebo during two intervention periods, each lasting seven days. Bowel movements were recorded daily, and gastrointestinal transit time was investigated with the wireless motility capsule system. Gastrointestinal symptoms, health-related quality of life, and CNS effects (pupil size, reaction time, memory, and general cognition) were also investigated, along with signs of addiction.
Eleven subjects (mean age: 45 ± 17 years, 46% males) with a median of 4.7 daily bowel movements were included. The number of daily bowel movements was reduced during opium tincture treatment to 2.3 (
= 0.045), but not placebo (3.0,
= 0.09). Opium tincture prolonged the colonic transit time compared to placebo (17 h vs. 12 h,
< 0.001). In both treatment arms, there were no changes in self-reported gastrointestinal symptoms, health-related quality of life, or CNS effects, and no indication of addiction was present.
Opium tincture induced anti-propulsive effects in patients with chronic diarrhea refractory to standard treatment. This indicates that opium tincture is a relevant treatment strategy for selected patients with chronic diarrhea. Moreover, no evidence of opioid-induced sedation or addiction was found.
NCT05690321 (registered 2023-01-10).</abstract><cop>England</cop><pmid>39054596</pmid><doi>10.1080/00365521.2024.2381694</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 2024-09, Vol.59 (9), p.1023-1034 |
| issn | 0036-5521 1502-7708 1502-7708 |
| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Aged Analgesics, Opioid - therapeutic use Chronic Disease Cross-Over Studies Defecation - drug effects Diarrhea - drug therapy Double-Blind Method Female Gastrointestinal Motility - drug effects Gastrointestinal Transit - drug effects Humans Male Middle Aged Opium - therapeutic use Quality of Life Treatment Outcome |
| title | Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial |
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