Copper ion-doped multifunctional hydrogel with mild photothermal enhancement promotes vascularized bone regeneration

The design and construction of a new and excellent synthetic graft is of great significance in the field of bone defect repair and reconstruction. In this study, a dopamine modified chitosan hydrogel doped with Cu ions with a mild photothermal effect was designed to provide a better microenvironment...

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Published in:Journal of biomaterials applications 2024-10, Vol.39 (4), p.332-342
Main Authors: Han, Chao, Lu, Dingsong, Yang, Suoping, Liu, Chong, Guo, Feng, Zhang, Kai, Li, Peng
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container_end_page 342
container_issue 4
container_start_page 332
container_title Journal of biomaterials applications
container_volume 39
creator Han, Chao
Lu, Dingsong
Yang, Suoping
Liu, Chong
Guo, Feng
Zhang, Kai
Li, Peng
description The design and construction of a new and excellent synthetic graft is of great significance in the field of bone defect repair and reconstruction. In this study, a dopamine modified chitosan hydrogel doped with Cu ions with a mild photothermal effect was designed to provide a better microenvironment to advance the bone repair via promote the angiogenesis and osteogenesis. Characterizations showed the successful synthesis of the material while it also presented excellent biocompatibility and mild photothermal effect under the irradiation of near-infrared light. Further, it could enhance the angiogenesis of HUVECs cells through promoting the ability of migration and tube formation and enhance the osteogenic differentiation of MC3T3-E1 cells via increasing the content of vital osteogenic factors including Runx2, Col-1, OPN, OCN, OSX, etc. The in vivo experiment also testified that it could promote the bone defect repair in rat models. These results indicate the multifunctional hydrogel is an ideal material for the treatment of bone defects and has good clinical application potential.
doi_str_mv 10.1177/08853282241268683
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title Copper ion-doped multifunctional hydrogel with mild photothermal enhancement promotes vascularized bone regeneration
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