Triterpenoid and trichothecenes from a rhizospheric soil-derived Paramyrothecium sp. KMU22107

A new phthalide derivative named paramlyktone ( ) and a new arborinane-type triterpenoid named paramyrpenoid ( ), together with ten previously described trichothecenes derivatives ( ) were isolated and identified from a rhizospheric soil-derived sp. KMU22107 associated with . Their structural elucid...

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Published in:Natural product research 2024-07, p.1-10
Main Authors: Li, Hong-Tao, Guo, Xing-Yi, Shao, Ya-Ting, Huang, Wen-Yu, Miao, Cui-Ping, Li, Wei
Format: Article
Language:English
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Summary:A new phthalide derivative named paramlyktone ( ) and a new arborinane-type triterpenoid named paramyrpenoid ( ), together with ten previously described trichothecenes derivatives ( ) were isolated and identified from a rhizospheric soil-derived sp. KMU22107 associated with . Their structural elucidation was achieved by the comprehensive analysis of spectroscopic data and comparison with literature values. Notably, paramyrpenoid ( ) was the first example of an arborinane-type triterpenoid with a double bond at Δ and an additional methyl motif at C-8. This was the first report of arborinane-type triterpenoids from a fungus belonging to genus. In pharmacological studies, paramyrpenoid ( ) demonstrated significant cytotoxic activity against the HL-60, SW480, A-549, MDA-MB-231 and SMMC-7721 cell lines, with IC values from 2.0 to 16.1 μM. Compounds and were also evaluated for anti-inflammatory, anti-acetylcholinesterase (AChE), and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities .
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2024.2383994