Loading…
Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus
Previous studies have demonstrated that the hippocampus, a crucial region for memory and cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals. Nickel (Ni) is a neurotoxic agent that, primarily induces oxidative stress, a process known to contribute to cellul...
Saved in:
Published in: | Biometals 2024-12, Vol.37 (6), p.1457-1469 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c256t-48fabe2d2879bd9e8c1f8c9f0a88c85901aecdc4466428a361799aa4d8d49e03 |
container_end_page | 1469 |
container_issue | 6 |
container_start_page | 1457 |
container_title | Biometals |
container_volume | 37 |
creator | El Brouzi, Mohamed Yassine Lamtai, Mouloud Fath, Nada Rezqaoui, Ayoub Zghari, Oussama El Hamzaoui, Abdelghafour Ibouzine-dine, Laila El Hessni, Aboubaker Mesfioui, Abdelhalem |
description | Previous studies have demonstrated that the hippocampus, a crucial region for memory and cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals. Nickel (Ni) is a neurotoxic agent that, primarily induces oxidative stress, a process known to contribute to cellular damage, which consequently affects neurological functions. The antioxidant properties of melatonin are a promising option for preventing the adverse effects of Ni, especially by protecting cells against oxidative stress and related damage. In our investigation of the potential neuroprotective effects of melatonin against Ni-induced neurotoxicity, we chose to administer melatonin through intraperitoneal injection in rats following an intrahippocampal injection of Ni into the left hippocampus. This approach allows us a targeted investigation into the influence of melatonin on the neurotoxic effects of Ni, particularly within the crucial context of the hippocampus. In the present study, we demonstrated that melatonin efficiency reduced lactate dehydrogenase level, and preserved antioxidant enzyme activities in Ni-exposed hippocampal tissue. It also mitigated the decline in superoxide dismutase and catalase activities. On the other hand, melatonin could act directly by reducing reactive oxygen species Ni-induced overproduction. Taking to gather these two potential mechanisms of action could be responsible for the adverse effect of Ni on the behavioral alteration observed in our study. This study provides significant insights into the potential of melatonin to mitigate the detrimental effects of Ni on the brain, particularly into the hippocampal region, suggesting its possible implications for the treatment of neurological disorders related to Ni exposure. |
doi_str_mv | 10.1007/s10534-024-00618-w |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3085117083</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3085117083</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-48fabe2d2879bd9e8c1f8c9f0a88c85901aecdc4466428a361799aa4d8d49e03</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0Eai9tX4AFisSGTWAcO_5ZoqoFpEpsurd8nUnr4sTBdmj79vg2BSQWLKzZfOeM5xxC3lD4QAHkx0yhZ7yFrj4QVLX3L8iO9rJrlZTsJdmBFqIFxfkxeZ3zHQBoCeKIHDMNAhTjOxIuHpYQk59vmnKLzYxrikuKBV3xP7FJMWATx2bCYEuc_dzYG-vnXJrZu-8YWj8Pq8NhE5b44J0vj03lDm4Bx9Lc-mWJzk7Lmk_Jq9GGjGfP84RcX15cn39pr759_nr-6ap1XS9Ky9Vo99gNnZJ6P2hUjo7K6RGsUk71GqhFNzjOheCdskxQqbW1fFAD1wjshLzfbOshP1bMxUw-OwzBzhjXbBionlJZA6jou3_Qu7imuX7OMMpB9lKrvlLdRrkUc044miX5yaZHQ8EcqjBbFaZWYZ6qMPdV9PbZet1POPyR_M6-AmwD8nLIH9Pf3f-x_QU3sZba</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3140757985</pqid></control><display><type>article</type><title>Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus</title><source>Springer Nature</source><creator>El Brouzi, Mohamed Yassine ; Lamtai, Mouloud ; Fath, Nada ; Rezqaoui, Ayoub ; Zghari, Oussama ; El Hamzaoui, Abdelghafour ; Ibouzine-dine, Laila ; El Hessni, Aboubaker ; Mesfioui, Abdelhalem</creator><creatorcontrib>El Brouzi, Mohamed Yassine ; Lamtai, Mouloud ; Fath, Nada ; Rezqaoui, Ayoub ; Zghari, Oussama ; El Hamzaoui, Abdelghafour ; Ibouzine-dine, Laila ; El Hessni, Aboubaker ; Mesfioui, Abdelhalem</creatorcontrib><description>Previous studies have demonstrated that the hippocampus, a crucial region for memory and cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals. Nickel (Ni) is a neurotoxic agent that, primarily induces oxidative stress, a process known to contribute to cellular damage, which consequently affects neurological functions. The antioxidant properties of melatonin are a promising option for preventing the adverse effects of Ni, especially by protecting cells against oxidative stress and related damage. In our investigation of the potential neuroprotective effects of melatonin against Ni-induced neurotoxicity, we chose to administer melatonin through intraperitoneal injection in rats following an intrahippocampal injection of Ni into the left hippocampus. This approach allows us a targeted investigation into the influence of melatonin on the neurotoxic effects of Ni, particularly within the crucial context of the hippocampus. In the present study, we demonstrated that melatonin efficiency reduced lactate dehydrogenase level, and preserved antioxidant enzyme activities in Ni-exposed hippocampal tissue. It also mitigated the decline in superoxide dismutase and catalase activities. On the other hand, melatonin could act directly by reducing reactive oxygen species Ni-induced overproduction. Taking to gather these two potential mechanisms of action could be responsible for the adverse effect of Ni on the behavioral alteration observed in our study. This study provides significant insights into the potential of melatonin to mitigate the detrimental effects of Ni on the brain, particularly into the hippocampal region, suggesting its possible implications for the treatment of neurological disorders related to Ni exposure.</description><identifier>ISSN: 0966-0844</identifier><identifier>ISSN: 1572-8773</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-024-00618-w</identifier><identifier>PMID: 39060834</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Catalase ; Cell Biology ; Cognitive ability ; Damage prevention ; Enzymatic activity ; Exposure ; Heavy metals ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Injection ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Life Sciences ; Male ; Medicine/Public Health ; Melatonin ; Melatonin - administration & dosage ; Melatonin - pharmacology ; Microbiology ; Neurological diseases ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Neurotoxicity ; Nickel ; Nickel - toxicity ; Oxidative stress ; Oxidative Stress - drug effects ; Pharmacology/Toxicology ; Plant Physiology ; Rats ; Rats, Wistar ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Side effects ; Superoxide dismutase</subject><ispartof>Biometals, 2024-12, Vol.37 (6), p.1457-1469</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>Copyright Springer Nature B.V. Dec 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-48fabe2d2879bd9e8c1f8c9f0a88c85901aecdc4466428a361799aa4d8d49e03</cites><orcidid>0000-0002-6978-3029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39060834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Brouzi, Mohamed Yassine</creatorcontrib><creatorcontrib>Lamtai, Mouloud</creatorcontrib><creatorcontrib>Fath, Nada</creatorcontrib><creatorcontrib>Rezqaoui, Ayoub</creatorcontrib><creatorcontrib>Zghari, Oussama</creatorcontrib><creatorcontrib>El Hamzaoui, Abdelghafour</creatorcontrib><creatorcontrib>Ibouzine-dine, Laila</creatorcontrib><creatorcontrib>El Hessni, Aboubaker</creatorcontrib><creatorcontrib>Mesfioui, Abdelhalem</creatorcontrib><title>Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus</title><title>Biometals</title><addtitle>Biometals</addtitle><addtitle>Biometals</addtitle><description>Previous studies have demonstrated that the hippocampus, a crucial region for memory and cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals. Nickel (Ni) is a neurotoxic agent that, primarily induces oxidative stress, a process known to contribute to cellular damage, which consequently affects neurological functions. The antioxidant properties of melatonin are a promising option for preventing the adverse effects of Ni, especially by protecting cells against oxidative stress and related damage. In our investigation of the potential neuroprotective effects of melatonin against Ni-induced neurotoxicity, we chose to administer melatonin through intraperitoneal injection in rats following an intrahippocampal injection of Ni into the left hippocampus. This approach allows us a targeted investigation into the influence of melatonin on the neurotoxic effects of Ni, particularly within the crucial context of the hippocampus. In the present study, we demonstrated that melatonin efficiency reduced lactate dehydrogenase level, and preserved antioxidant enzyme activities in Ni-exposed hippocampal tissue. It also mitigated the decline in superoxide dismutase and catalase activities. On the other hand, melatonin could act directly by reducing reactive oxygen species Ni-induced overproduction. Taking to gather these two potential mechanisms of action could be responsible for the adverse effect of Ni on the behavioral alteration observed in our study. This study provides significant insights into the potential of melatonin to mitigate the detrimental effects of Ni on the brain, particularly into the hippocampal region, suggesting its possible implications for the treatment of neurological disorders related to Ni exposure.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Catalase</subject><subject>Cell Biology</subject><subject>Cognitive ability</subject><subject>Damage prevention</subject><subject>Enzymatic activity</subject><subject>Exposure</subject><subject>Heavy metals</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Injection</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicine/Public Health</subject><subject>Melatonin</subject><subject>Melatonin - administration & dosage</subject><subject>Melatonin - pharmacology</subject><subject>Microbiology</subject><subject>Neurological diseases</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neurotoxicity</subject><subject>Nickel</subject><subject>Nickel - toxicity</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Side effects</subject><subject>Superoxide dismutase</subject><issn>0966-0844</issn><issn>1572-8773</issn><issn>1572-8773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhS0Eai9tX4AFisSGTWAcO_5ZoqoFpEpsurd8nUnr4sTBdmj79vg2BSQWLKzZfOeM5xxC3lD4QAHkx0yhZ7yFrj4QVLX3L8iO9rJrlZTsJdmBFqIFxfkxeZ3zHQBoCeKIHDMNAhTjOxIuHpYQk59vmnKLzYxrikuKBV3xP7FJMWATx2bCYEuc_dzYG-vnXJrZu-8YWj8Pq8NhE5b44J0vj03lDm4Bx9Lc-mWJzk7Lmk_Jq9GGjGfP84RcX15cn39pr759_nr-6ap1XS9Ky9Vo99gNnZJ6P2hUjo7K6RGsUk71GqhFNzjOheCdskxQqbW1fFAD1wjshLzfbOshP1bMxUw-OwzBzhjXbBionlJZA6jou3_Qu7imuX7OMMpB9lKrvlLdRrkUc044miX5yaZHQ8EcqjBbFaZWYZ6qMPdV9PbZet1POPyR_M6-AmwD8nLIH9Pf3f-x_QU3sZba</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>El Brouzi, Mohamed Yassine</creator><creator>Lamtai, Mouloud</creator><creator>Fath, Nada</creator><creator>Rezqaoui, Ayoub</creator><creator>Zghari, Oussama</creator><creator>El Hamzaoui, Abdelghafour</creator><creator>Ibouzine-dine, Laila</creator><creator>El Hessni, Aboubaker</creator><creator>Mesfioui, Abdelhalem</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6978-3029</orcidid></search><sort><creationdate>20241201</creationdate><title>Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus</title><author>El Brouzi, Mohamed Yassine ; Lamtai, Mouloud ; Fath, Nada ; Rezqaoui, Ayoub ; Zghari, Oussama ; El Hamzaoui, Abdelghafour ; Ibouzine-dine, Laila ; El Hessni, Aboubaker ; Mesfioui, Abdelhalem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-48fabe2d2879bd9e8c1f8c9f0a88c85901aecdc4466428a361799aa4d8d49e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Catalase</topic><topic>Cell Biology</topic><topic>Cognitive ability</topic><topic>Damage prevention</topic><topic>Enzymatic activity</topic><topic>Exposure</topic><topic>Heavy metals</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Injection</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medicine/Public Health</topic><topic>Melatonin</topic><topic>Melatonin - administration & dosage</topic><topic>Melatonin - pharmacology</topic><topic>Microbiology</topic><topic>Neurological diseases</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neurotoxicity</topic><topic>Nickel</topic><topic>Nickel - toxicity</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology/Toxicology</topic><topic>Plant Physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Side effects</topic><topic>Superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Brouzi, Mohamed Yassine</creatorcontrib><creatorcontrib>Lamtai, Mouloud</creatorcontrib><creatorcontrib>Fath, Nada</creatorcontrib><creatorcontrib>Rezqaoui, Ayoub</creatorcontrib><creatorcontrib>Zghari, Oussama</creatorcontrib><creatorcontrib>El Hamzaoui, Abdelghafour</creatorcontrib><creatorcontrib>Ibouzine-dine, Laila</creatorcontrib><creatorcontrib>El Hessni, Aboubaker</creatorcontrib><creatorcontrib>Mesfioui, Abdelhalem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biometals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Brouzi, Mohamed Yassine</au><au>Lamtai, Mouloud</au><au>Fath, Nada</au><au>Rezqaoui, Ayoub</au><au>Zghari, Oussama</au><au>El Hamzaoui, Abdelghafour</au><au>Ibouzine-dine, Laila</au><au>El Hessni, Aboubaker</au><au>Mesfioui, Abdelhalem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus</atitle><jtitle>Biometals</jtitle><stitle>Biometals</stitle><addtitle>Biometals</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>37</volume><issue>6</issue><spage>1457</spage><epage>1469</epage><pages>1457-1469</pages><issn>0966-0844</issn><issn>1572-8773</issn><eissn>1572-8773</eissn><abstract>Previous studies have demonstrated that the hippocampus, a crucial region for memory and cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals. Nickel (Ni) is a neurotoxic agent that, primarily induces oxidative stress, a process known to contribute to cellular damage, which consequently affects neurological functions. The antioxidant properties of melatonin are a promising option for preventing the adverse effects of Ni, especially by protecting cells against oxidative stress and related damage. In our investigation of the potential neuroprotective effects of melatonin against Ni-induced neurotoxicity, we chose to administer melatonin through intraperitoneal injection in rats following an intrahippocampal injection of Ni into the left hippocampus. This approach allows us a targeted investigation into the influence of melatonin on the neurotoxic effects of Ni, particularly within the crucial context of the hippocampus. In the present study, we demonstrated that melatonin efficiency reduced lactate dehydrogenase level, and preserved antioxidant enzyme activities in Ni-exposed hippocampal tissue. It also mitigated the decline in superoxide dismutase and catalase activities. On the other hand, melatonin could act directly by reducing reactive oxygen species Ni-induced overproduction. Taking to gather these two potential mechanisms of action could be responsible for the adverse effect of Ni on the behavioral alteration observed in our study. This study provides significant insights into the potential of melatonin to mitigate the detrimental effects of Ni on the brain, particularly into the hippocampal region, suggesting its possible implications for the treatment of neurological disorders related to Ni exposure.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39060834</pmid><doi>10.1007/s10534-024-00618-w</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-6978-3029</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0966-0844 |
ispartof | Biometals, 2024-12, Vol.37 (6), p.1457-1469 |
issn | 0966-0844 1572-8773 1572-8773 |
language | eng |
recordid | cdi_proquest_miscellaneous_3085117083 |
source | Springer Nature |
subjects | Animals Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Biochemistry Biomedical and Life Sciences Catalase Cell Biology Cognitive ability Damage prevention Enzymatic activity Exposure Heavy metals Hippocampus Hippocampus - drug effects Hippocampus - metabolism Injection L-Lactate dehydrogenase Lactate dehydrogenase Life Sciences Male Medicine/Public Health Melatonin Melatonin - administration & dosage Melatonin - pharmacology Microbiology Neurological diseases Neuroprotection Neuroprotective Agents - pharmacology Neurotoxicity Nickel Nickel - toxicity Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Plant Physiology Rats Rats, Wistar Reactive oxygen species Reactive Oxygen Species - metabolism Side effects Superoxide dismutase |
title | Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A16%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exploring%20the%20neuroprotective%20role%20of%20melatonin%20against%20nickel-induced%20neurotoxicity%20in%20the%20left%20hippocampus&rft.jtitle=Biometals&rft.au=El%20Brouzi,%20Mohamed%20Yassine&rft.date=2024-12-01&rft.volume=37&rft.issue=6&rft.spage=1457&rft.epage=1469&rft.pages=1457-1469&rft.issn=0966-0844&rft.eissn=1572-8773&rft_id=info:doi/10.1007/s10534-024-00618-w&rft_dat=%3Cproquest_cross%3E3085117083%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c256t-48fabe2d2879bd9e8c1f8c9f0a88c85901aecdc4466428a361799aa4d8d49e03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3140757985&rft_id=info:pmid/39060834&rfr_iscdi=true |