Infections with Klebsiella pneumoniae in Children Undergoing Anticancer Therapy or Hematopoietic Cell Transplantation: A Multicenter Nationwide Study

• Published in: Journal of clinical medicine 2024-07, Vol.13 (14), p.4078
• Main Authors: Sękowska, Alicja, Czyżewski, Krzysztof, Jaremek, Kamila, Zalas-Więcek, Patrycja, Zając-Spychała, Olga, Wachowiak, Jacek, Szmydki-Baran, Anna, Hutnik, Łukasz, Gietka, Agnieszka, Gryniewicz-Kwiatkowska, Olga, Dembowska-Bagińska, Bożenna, Semczuk, Katarzyna, Dzierżanowska-Fangrat, Katarzyna, Czogała, Wojciech, Balwierz, Walentyna, Żak, Iwona, Tomaszewska, Renata, Szczepański, Tomasz, Bień, Ewa, Irga-Jaworska, Ninela, Machnik, Katarzyna, Urbańska-Rakus, Justyna, Pająk, Sonia, Płonowski, Marcin, Krawczuk-Rybak, Maryna, Królak, Aleksandra, Ociepa, Tomasz, Urasiński, Tomasz, Wawryków, Paweł, Peregud-Pogorzelski, Jarosław, Brzeski, Tomasz, Mycko, Katarzyna, Mańko-Glińska, Hanna, Badowska, Wanda, Urbanek-Dądela, Agnieszka, Karolczyk, Grażyna, Stolpa, Weronika, Skowron-Kandzia, Katarzyna, Mizia-Malarz, Agnieszka, Pierlejewski, Filip, Młynarski, Wojciech, Musiał, Jakub, Chaber, Radosław, Zawitkowska, Joanna, Zaucha-Prażmo, Agnieszka, Drabko, Katarzyna, Goździk, Jolanta, Frączkiewicz, Jowita, Salamonowicz-Bodzioch, Małgorzata, Kałwak, Krzysztof, Styczyński, Jan
• Format: Article
• Language: English
• Subjects: Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; Cancer therapies; Disease prevention; Drug dosages; Drug resistance; Hematology; Immune system; Leukemia; Mortality; Nervous system; Neutropenia; Oncology; Pathogens; Patients; Pediatrics; Pneumonia; Risk factors; Stem cell transplantation; Tumors; Urinary tract diseases; Urinary tract infections; Urogenital system
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm13144078

is a nosocomial pathogen that causes severe infections in immunocompromised patients. The aim of the study was to conduct a microbiological and clinical analysis of infections in children with malignancies or undergoing hematopoietic cell transplantation in Poland. We conducted a retrospective, multicenter study including children and adolescents under 19 years old treated between 2012 and 2021. We analyzed patients' characteristics, microbiological data, and the outcomes of antibiotic therapy. : A total of 9121 newly diagnosed children were treated for malignancy and 1697 pediatric patients underwent hematopoietic cell transplantation. infections were diagnosed in 527 patients. Their overall incidence was 4.86% in pediatric hematology and oncology patients and 4.95% in patients who underwent hematopoietic cell transplantation. The incidence of infection was higher in patients with acute leukemia than with solid tumors (7.8% vs. 4.1%; OR = 2.0; 95% CI = 1.6-2.4; < 0.0001). The most frequent source of infection was in the urinary tract at 55.2%. More than 57% of strains were extended-spectrum β-lactamase-positive and almost 34% were multidrug-resistant. Infections with contributed to death in 3.22% of patients. : is one of the most critical pathogens in children suffering from malignancies or undergoing hematopoietic cell transplantation. The incidence of multidrug-resistant strains is increasing and contributing to poor clinical outcome.