Nanocellulose/Nanoporous Silicon Composite Films as a Drug Delivery System

Nanocellulose (NC) is a promising material for drug delivery due to its high surface area-to-volume ratio, biocompatibility, biodegradability, and versatility in various formats (nanoparticles, hydrogels, microspheres, membranes, and films). In this study, nanocellulose films were derived from "...

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Bibliographic Details
Published in:Polymers 2024-07, Vol.16 (14), p.2055
Main Authors: Garrido-Miranda, Karla A, Pesenti, Héctor, Contreras, Angel, Vergara-Figueroa, Judith, Recio-Sánchez, Gonzalo, Chumpitaz, Dalton, Ponce, Silvia, Hernandez-Montelongo, Jacobo
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Bacteria
Biocompatibility
Cellulose
Composite materials
Diffusion coefficient
Drug delivery systems
Drugs
E coli
Elastic properties
Fourier transforms
Hydrogen bonds
Infrared analysis
Infrared spectroscopy
Mechanical properties
Methylene blue
Microparticles
Microspheres
Modulus of elasticity
Nanoparticles
Polyvinyl alcohol
Silicon
Spectrum analysis
Thermogravimetric analysis
Toxicity
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Summary:Nanocellulose (NC) is a promising material for drug delivery due to its high surface area-to-volume ratio, biocompatibility, biodegradability, and versatility in various formats (nanoparticles, hydrogels, microspheres, membranes, and films). In this study, nanocellulose films were derived from "Bolaina blanca" ( ) and combined with nanoporous silicon microparticles (nPSi) in concentrations ranging from 0.1% to 1.0% ( / ), using polyvinyl alcohol (PVA) as a binding agent to create NC/nPSi composite films for drug delivery systems. The physicochemical properties of the samples were characterized using UV-Vis spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The mechanical properties and drug release capabilities were also evaluated using methylene blue (MB) as an antibacterial drug model. Antibacterial assays were conducted against and bacteria. The results show that NC/nPSi composites with 1% nPSi increased the T by 10 °C and enhanced mechanical properties, such as a 70% increase in the elastic modulus and a 372% increase in elongation, compared to NC films. Additionally, MB released from NC/nPSi composites effectively inhibited the growth of both bacteria. It was also observed that the diffusion coefficients were inversely proportional to the % nPSi. These findings suggest that this novel NC/nPSi-based material can serve as an effective controlled drug release system.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym16142055