Production and physico-chemical characterization of nano-sized collagen from equine tendon

In recent years, significant academic and commercial interest has focused on collagen derived from horse tendons, with potential applications across diverse sectors such as medicine, pharmaceuticals, and cosmetics. Nano collagen, with its enhanced wound penetration, improved cell contact, and height...

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Published in:International journal of biological macromolecules 2024-10, Vol.277 (Pt 2), p.134220, Article 134220
Main Authors: Rajabimashhadi, Zahra, Gallo, Nunzia, Russo, Francesca, Ghiyami, Sajjad, Mele, Claudio, Giordano, Maria Elena, Lionetto, Maria Giulia, Salvatore, Luca, Lionetto, Francesca
Format: Article
Language:English
Subjects:
Animals
Ball-milling
Biocompatible Materials - chemistry
Chemical Phenomena
Collagen - chemistry
Equine collagen
Horses
Nano collagen
Nanoparticles - chemistry
Particle Size
Particle size reduction
Temperature
Tendons - chemistry
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Summary:In recent years, significant academic and commercial interest has focused on collagen derived from horse tendons, with potential applications across diverse sectors such as medicine, pharmaceuticals, and cosmetics. Nano collagen, with its enhanced wound penetration, improved cell contact, and heightened cellular regeneration and repair capabilities due to its high surface area, holds promise for a wide range of applications. In this study, we present a novel method for producing nano collagen from the equine tendon. Our approach is characterized by its speed, affordability, simplicity and environmentally friendly nature, with precise temperature-control to prevent collagen denaturation. We conducted a comprehensive characterization of the obtained samples, including assessments of morphology, chemical and thermal properties, particle size distribution and biocompatibility. Importantly, our results indicate improvements in thermal stability, and surface roughness of nano collagen, while preserving its molecular weight. These advancements expand the potential applications of nano collagen in various fields. [Display omitted] •Swift, cheap and environmentally conscious nano-sized collagen by ball milling•Effect of the mechanical treatment on the microstructure, size and thermal stability•Improvement in thermal stability and surface roughness of nano collagen•Increase of collagen application range guaranteed by the nanometric size
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.134220