Identification of neurotransmitter imbalances in the cingulate cortex of NMOSD patients using magnetic resonance spectroscopy

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-07, Vol.34 (7)
• Main Authors: Zhao, Min, Li, Xiao, Li, Fuyan, Hu, Xin, Wang, Jing, Liu, Yuxi, Zhang, Chuanchen, Bai, Jie, Edden, Richard A E, Gao, Fei, Su, Meixia, Ren, Fuxin
• Format: Article
• Language: English
• Subjects: Adult; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - metabolism; Female; gamma-Aminobutyric Acid - metabolism; Glutamic Acid - metabolism; Glutathione - metabolism; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - metabolism; Humans; Magnetic Resonance Spectroscopy - methods; Male; Middle Aged; Neuromyelitis Optica - diagnostic imaging; Neuromyelitis Optica - metabolism; Neurotransmitter Agents - metabolism; Young Adult
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhae304

Abstract Cognitive impairment affects 29–67% of patients with neuromyelitis optica spectrum disorder. Previous studies have reported glutamate homeostasis disruptions in astrocytes, leading to imbalances in gamma-aminobutyric acid levels. However, the association between these neurotransmitter changes and cognitive deficits remains inadequately elucidated. Point RESolved Spectroscopy and Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy techniques were utilized to evaluate gamma-aminobutyric acid, glutamate, glutathione levels, and excitation/inhibition balance in the anterior cingulate cortex, posterior cingulate cortex, and occipital cortex of 39 neuromyelitis optica spectrum disorder patients and 41 healthy controls. Cognitive function was assessed using neurocognitive scales. Results showed decreased gamma-aminobutyric acid levels alongside increased glutamate, glutathione, and excitation/inhibition ratio in the anterior cingulate cortex and posterior cingulate cortex of neuromyelitis optica spectrum disorder patients. Specifically, within the posterior cingulate cortex of neuromyelitis optica spectrum disorder patients, decreased gamma-aminobutyric acid levels and increased excitation/inhibition ratio correlated significantly with anxiety scores, whereas glutathione levels predicted diminished executive function. The results suggest that neuromyelitis optica spectrum disorder patients exhibit dysregulation in the GABAergic and glutamatergic systems in their brains, where the excitation/inhibition imbalance potentially acts as a neuronal metabolic factor contributing to emotional disorders. Additionally, glutathione levels in the posterior cingulate cortex region may serve as predictors of cognitive decline, highlighting the potential benefits of reducing oxidative stress to safeguard cognitive function in neuromyelitis optica spectrum disorder patients.