Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study

A potential association between breast (BC) and thyroid cancer (TC) has been observed. We investigated if the relationship between BC and TC is causal using bidirectional Mendelian randomization (MR) in Asian and European populations. BC-linked single nucleotide polymorphisms (SNPs) were acquired fr...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2024-07
Main Authors: Xu, Jing-Xuan, Chen, Yuan-Yuan, Qi, Lu-Nan, Peng, Yu-Chong
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c184t-289a59d9dff5182d985b112c373e132f02f0d273a0dfca0e37e358e35d2ea5a33
container_end_page
container_issue
container_start_page
container_title Endocrine
container_volume
creator Xu, Jing-Xuan
Chen, Yuan-Yuan
Qi, Lu-Nan
Peng, Yu-Chong
description A potential association between breast (BC) and thyroid cancer (TC) has been observed. We investigated if the relationship between BC and TC is causal using bidirectional Mendelian randomization (MR) in Asian and European populations. BC-linked single nucleotide polymorphisms (SNPs) were acquired from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium and Biobank Japan. The most recent TC GWAS data were obtained from the FinnGen Project and National Biobank of Korea. We assessed the potential causal relationship between BC and TC using various MR methods, including inverse-variance-weighting (IVW). Sensitivity, heterogeneity, and pleiotropic tests were performed to assess reliability. We found a bidirectional causal association between BC and TC within Europeans (IVW, TC on BC: odds ratio [OR] 1.090, 95% confidence interval [CI]: 1.012-1.173, P = 0.023; BC on TC: OR 1.265, 95% CI: 1.158-1.381, P 
doi_str_mv 10.1007/s12020-024-03976-0
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3086061974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086061974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c184t-289a59d9dff5182d985b112c373e132f02f0d273a0dfca0e37e358e35d2ea5a33</originalsourceid><addsrcrecordid>eNpNkctOwzAQRS0EoqXwAyyQl2wMY7uJE3ao4lGpiA2sIyeeUKM8ip1Qlc_gi3GbgpBsz2h854w0l5BzDlccQF17LkAAAzFlIFMVMzggYx5FKYPwf_gvH5ET798BhBCxOiYjmYKKhIrH5HvefKLv7JvubNvQtqTdEmmhe68r6rDalf3SrmiO3RqxoblD7bsgaQp0VDcmdGxca82-dEM19djtUOuWeV2vKqS5NdZhsaUF8BM2BiurG-oCoK3t1zDed73ZnJKjUlcez_ZxQl7v715mj2zx_DCf3S5YwZNpx0SS6ig1qSnLiCfCpEmUcy4KqSRyKUoIxwglNZiy0IBSoYyScI1AHWkpJ-Ry4K5c-9GHJWS19QVWlW6w7X0mIYkh5qmaBqkYpIVrvXdYZitna-02GYds60U2eJEFL7KdF-GdkIs9v89rNH8tv8uXP5Vyh90</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086061974</pqid></control><display><type>article</type><title>Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study</title><source>Springer Link</source><creator>Xu, Jing-Xuan ; Chen, Yuan-Yuan ; Qi, Lu-Nan ; Peng, Yu-Chong</creator><creatorcontrib>Xu, Jing-Xuan ; Chen, Yuan-Yuan ; Qi, Lu-Nan ; Peng, Yu-Chong</creatorcontrib><description>A potential association between breast (BC) and thyroid cancer (TC) has been observed. We investigated if the relationship between BC and TC is causal using bidirectional Mendelian randomization (MR) in Asian and European populations. BC-linked single nucleotide polymorphisms (SNPs) were acquired from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium and Biobank Japan. The most recent TC GWAS data were obtained from the FinnGen Project and National Biobank of Korea. We assessed the potential causal relationship between BC and TC using various MR methods, including inverse-variance-weighting (IVW). Sensitivity, heterogeneity, and pleiotropic tests were performed to assess reliability. We found a bidirectional causal association between BC and TC within Europeans (IVW, TC on BC: odds ratio [OR] 1.090, 95% confidence interval [CI]: 1.012-1.173, P = 0.023; BC on TC: OR 1.265, 95% CI: 1.158-1.381, P &lt; 0.001). A one-way causal relationship between BC susceptibility and TC risk was found in Asians (IVW BC on TC: OR 2.274, 95% CI: 2.089-2.475, P &lt; 0.001). Subsequently, we identified a noteworthy bidirectional causal relationship between estrogen receptor (ER)-positive BC and TC (IVW, TC on ER-positive BC: OR 1.104, 95% CI: 1.001-1.212, P = 0.038; ER-positive BC on TC: OR 1.223, 95%CI: 1.072-1.395, P = 0.003), but not ER-negative BC and TC in Europeans. We revealed a reciprocal causal association between ER-positive BC and TC. These findings establish a theoretical framework for the simultaneous surveillance and treatment of BC and TC.</description><identifier>ISSN: 1559-0100</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-024-03976-0</identifier><identifier>PMID: 39075276</identifier><language>eng</language><publisher>United States</publisher><ispartof>Endocrine, 2024-07</ispartof><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c184t-289a59d9dff5182d985b112c373e132f02f0d273a0dfca0e37e358e35d2ea5a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39075276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Jing-Xuan</creatorcontrib><creatorcontrib>Chen, Yuan-Yuan</creatorcontrib><creatorcontrib>Qi, Lu-Nan</creatorcontrib><creatorcontrib>Peng, Yu-Chong</creatorcontrib><title>Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study</title><title>Endocrine</title><addtitle>Endocrine</addtitle><description>A potential association between breast (BC) and thyroid cancer (TC) has been observed. We investigated if the relationship between BC and TC is causal using bidirectional Mendelian randomization (MR) in Asian and European populations. BC-linked single nucleotide polymorphisms (SNPs) were acquired from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium and Biobank Japan. The most recent TC GWAS data were obtained from the FinnGen Project and National Biobank of Korea. We assessed the potential causal relationship between BC and TC using various MR methods, including inverse-variance-weighting (IVW). Sensitivity, heterogeneity, and pleiotropic tests were performed to assess reliability. We found a bidirectional causal association between BC and TC within Europeans (IVW, TC on BC: odds ratio [OR] 1.090, 95% confidence interval [CI]: 1.012-1.173, P = 0.023; BC on TC: OR 1.265, 95% CI: 1.158-1.381, P &lt; 0.001). A one-way causal relationship between BC susceptibility and TC risk was found in Asians (IVW BC on TC: OR 2.274, 95% CI: 2.089-2.475, P &lt; 0.001). Subsequently, we identified a noteworthy bidirectional causal relationship between estrogen receptor (ER)-positive BC and TC (IVW, TC on ER-positive BC: OR 1.104, 95% CI: 1.001-1.212, P = 0.038; ER-positive BC on TC: OR 1.223, 95%CI: 1.072-1.395, P = 0.003), but not ER-negative BC and TC in Europeans. We revealed a reciprocal causal association between ER-positive BC and TC. These findings establish a theoretical framework for the simultaneous surveillance and treatment of BC and TC.</description><issn>1559-0100</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNkctOwzAQRS0EoqXwAyyQl2wMY7uJE3ao4lGpiA2sIyeeUKM8ip1Qlc_gi3GbgpBsz2h854w0l5BzDlccQF17LkAAAzFlIFMVMzggYx5FKYPwf_gvH5ET798BhBCxOiYjmYKKhIrH5HvefKLv7JvubNvQtqTdEmmhe68r6rDalf3SrmiO3RqxoblD7bsgaQp0VDcmdGxca82-dEM19djtUOuWeV2vKqS5NdZhsaUF8BM2BiurG-oCoK3t1zDed73ZnJKjUlcez_ZxQl7v715mj2zx_DCf3S5YwZNpx0SS6ig1qSnLiCfCpEmUcy4KqSRyKUoIxwglNZiy0IBSoYyScI1AHWkpJ-Ry4K5c-9GHJWS19QVWlW6w7X0mIYkh5qmaBqkYpIVrvXdYZitna-02GYds60U2eJEFL7KdF-GdkIs9v89rNH8tv8uXP5Vyh90</recordid><startdate>20240729</startdate><enddate>20240729</enddate><creator>Xu, Jing-Xuan</creator><creator>Chen, Yuan-Yuan</creator><creator>Qi, Lu-Nan</creator><creator>Peng, Yu-Chong</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240729</creationdate><title>Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study</title><author>Xu, Jing-Xuan ; Chen, Yuan-Yuan ; Qi, Lu-Nan ; Peng, Yu-Chong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c184t-289a59d9dff5182d985b112c373e132f02f0d273a0dfca0e37e358e35d2ea5a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Jing-Xuan</creatorcontrib><creatorcontrib>Chen, Yuan-Yuan</creatorcontrib><creatorcontrib>Qi, Lu-Nan</creatorcontrib><creatorcontrib>Peng, Yu-Chong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Jing-Xuan</au><au>Chen, Yuan-Yuan</au><au>Qi, Lu-Nan</au><au>Peng, Yu-Chong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study</atitle><jtitle>Endocrine</jtitle><addtitle>Endocrine</addtitle><date>2024-07-29</date><risdate>2024</risdate><issn>1559-0100</issn><eissn>1559-0100</eissn><abstract>A potential association between breast (BC) and thyroid cancer (TC) has been observed. We investigated if the relationship between BC and TC is causal using bidirectional Mendelian randomization (MR) in Asian and European populations. BC-linked single nucleotide polymorphisms (SNPs) were acquired from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium and Biobank Japan. The most recent TC GWAS data were obtained from the FinnGen Project and National Biobank of Korea. We assessed the potential causal relationship between BC and TC using various MR methods, including inverse-variance-weighting (IVW). Sensitivity, heterogeneity, and pleiotropic tests were performed to assess reliability. We found a bidirectional causal association between BC and TC within Europeans (IVW, TC on BC: odds ratio [OR] 1.090, 95% confidence interval [CI]: 1.012-1.173, P = 0.023; BC on TC: OR 1.265, 95% CI: 1.158-1.381, P &lt; 0.001). A one-way causal relationship between BC susceptibility and TC risk was found in Asians (IVW BC on TC: OR 2.274, 95% CI: 2.089-2.475, P &lt; 0.001). Subsequently, we identified a noteworthy bidirectional causal relationship between estrogen receptor (ER)-positive BC and TC (IVW, TC on ER-positive BC: OR 1.104, 95% CI: 1.001-1.212, P = 0.038; ER-positive BC on TC: OR 1.223, 95%CI: 1.072-1.395, P = 0.003), but not ER-negative BC and TC in Europeans. We revealed a reciprocal causal association between ER-positive BC and TC. These findings establish a theoretical framework for the simultaneous surveillance and treatment of BC and TC.</abstract><cop>United States</cop><pmid>39075276</pmid><doi>10.1007/s12020-024-03976-0</doi></addata></record>
fulltext fulltext
identifier ISSN: 1559-0100
ispartof Endocrine, 2024-07
issn 1559-0100
1559-0100
language eng
recordid cdi_proquest_miscellaneous_3086061974
source Springer Link
title Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A27%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20the%20causal%20relationship%20between%20breast%20cancer%20and%20thyroid%20cancer:%20a%20set%20of%20two-sample%20bidirectional%20Mendelian%20randomization%20study&rft.jtitle=Endocrine&rft.au=Xu,%20Jing-Xuan&rft.date=2024-07-29&rft.issn=1559-0100&rft.eissn=1559-0100&rft_id=info:doi/10.1007/s12020-024-03976-0&rft_dat=%3Cproquest_cross%3E3086061974%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c184t-289a59d9dff5182d985b112c373e132f02f0d273a0dfca0e37e358e35d2ea5a33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3086061974&rft_id=info:pmid/39075276&rfr_iscdi=true