Associations of 10-year atherosclerotic cardiovascular disease risk scores with cerebral small vessel disease: the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study

• Published in: Age and ageing 2024-07, Vol.53 (7)
• Main Authors: Liu, Dandan, Zhang, Yanli, Cai, Xueli, Yang, Yingying, Wang, Suying, Mei, Lerong, Jing, Jing, Li, Shan, Wang, Mengxing, Meng, Xia, Wei, Tiemin, Wang, Yongjun, Wang, Yilong, Pan, Yuesong
• Format: Article
• Language: English
• Subjects: Aged; Arteriosclerosis; Atherosclerosis; Atherosclerosis - diagnosis; Atherosclerosis - diagnostic imaging; Atherosclerosis - epidemiology; Basal ganglia; Cardiovascular disease; Cardiovascular diseases; Cerebral Small Vessel Diseases - diagnostic imaging; Cerebral Small Vessel Diseases - epidemiology; China - epidemiology; Cognitive ability; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - epidemiology; Cognitive impairment; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Predictive Value of Tests; Risk Assessment; Risk Factors; Stratification; Substantia alba; Vascular diseases
• ISSN: 0002-0729; 1468-2834; 1468-2834
• DOI: 10.1093/ageing/afae161

Abstract Background 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores were useful for predicting large vessel disease, but the relationships between them and cerebral small vessel disease (CSVD) were unclear. Our study aimed to evaluate associations of 10-year ASCVD risk scores with CSVD and its magnetic resonance imaging (MRI) markers. Methods Community-dwelling residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included in this cross-sectional study. At baseline, we collected data related to the Framingham Risk Score (FRS), pooled cohort equation (PCE), prediction for ASCVD risk in China (China-PAR) and Systematic COronary Risk Evaluation model 2 (SCORE2), and classified participants into low, moderate and high groups. Participants underwent brain MRI scans. We evaluated white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS) according to criteria of Wardlaw and Rothwell, and calculated total CSVD score and modified total CSVD score. Results A total of 3063 participants were included, and 53.5% of them were female. A higher FRS was associated with higher total CSVD score (moderate vs. low: cOR 1.89, 95% CI 1.53–2.34; high vs. low: cOR 3.23, 95%CI 2.62–3.97), and the PCE, China-PAR or SCORE2 score was positively related to total CSVD score (P