New Flavan Derivatives from the Leaves and Stems of Cassia Nodosa

• Published in: Chemistry & biodiversity 2024-11, Vol.21 (11), p.e202401431-n/a
• Main Authors: Sun, Qiong‐Hui, Yu, Li‐Mei, Yan, Wen, Cheng, Hao, Zhan, Rui, Chen, Ye‐Gao
• Format: Article
• Language: English
• Subjects: Animals; Antioxidant; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Benzothiazoles; Biphenyl Compounds - antagonists & inhibitors; Cassia - chemistry; Cassia nodosa; Cell Line, Tumor; Cell Survival - drug effects; Chemical composition; Cytotoxicity; Flavan derivatives; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Glucosidase; Glycoside Hydrolase Inhibitors - chemistry; Glycoside Hydrolase Inhibitors - isolation & purification; Glycoside Hydrolase Inhibitors - pharmacology; Humans; Leaves; Methane; Molecular Structure; Picrates - antagonists & inhibitors; Plant Leaves - chemistry; Plant Stems - chemistry; Scavenging; Stems; Sulfonic Acids
• ISSN: 1612-1872; 1612-1880; 1612-1880
• DOI: 10.1002/cbdv.202401431

Three new flavan derivatives including two methylene‐linked flavan‐3‐ol dimers, bis(8‐epiafzelechinyl)methane (1), and 8,8‐(epiafzelechin‐afzelechin)methane (2), a flavan‐3‐ol monomer, (−)‐3‐O‐acetyl‐epiafzelechin (3) and four known related compounds (4–7) were isolated from the leaves and stems of Cassia nodosa. Their structures were elucidated by extensive spectroscopic analyses and CD data. The isolates were evaluated for their antioxidant, α‐glucosidase inhibitory, cytotoxic and neuroinflammatory activities, and compound 3 exhibited remarkable radical scavenging activities in both the DPPH and ABTS models with IC50 values of 2.65±1.25, and 4.78±0.91 μg/mL, respectively.