Possible pitfalls in the prediction of weight gain in middle-aged normal-weight individuals: Results from the NDB-K7Ps-study-2

The prevalence of obesity has not decreased worldwide and obesity-related morbidities have been increasing steadily. However, few studies have investigated factors contributing to weight gain in normal-weight individuals. Thus, in this community-based cohort study, we aimed to investigate factors co...

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Bibliographic Details
Published in:Obesity research & clinical practice 2024-07, Vol.18 (4), p.255-262
Main Authors: Nakajima, Kei, Sekine, Airi, Higuchi, Ryoko, Enokido, Mai, Matsui, Sadako
Format: Article
Language:English
Subjects:
Glycated hemoglobin
Machine learning
Smoking
Triglyceride
Weight gain
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Summary:The prevalence of obesity has not decreased worldwide and obesity-related morbidities have been increasing steadily. However, few studies have investigated factors contributing to weight gain in normal-weight individuals. Thus, in this community-based cohort study, we aimed to investigate factors contributing to weight gain in normal-weight participants. Clinical variables and 10 % increase in weight over 10 years (10 %IBW10Y) were retrospectively investigated in apparently healthy 615,077 normal-weight (body mass index (BMI) 21.0–24.9 kg/m2) participants aged 40–64 years who had regularly undergone health checkup. Machine learning and logistic regression analysis (nested case-control study) were used to predict 10 %IBW10Y. In total, 6.8 % of men and 8.9 % of women had 10 %IBW10Y (P 
ISSN:1871-403X
DOI:10.1016/j.orcp.2024.07.004