Incidence and prevalence of Alzheimer’s disease in China: a systematic review and meta-analysis

As China faces demographic shifts and socioeconomic changes, the burden of Alzheimer’s disease (AD) and associated cognitive impairments is increasing dramatically, with significant implications for public health and the economy. This systematic review and meta-analysis aims to provide a comprehensi...

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Bibliographic Details
Published in:European journal of epidemiology 2024-07, Vol.39 (7), p.701-714
Main Authors: Ji, Qianqian, Chen, Jingqi, Li, Yafei, Tao, Enxiang, Zhan, Yiqiang
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - epidemiology
Alzheimer's disease
Cardiology
China - epidemiology
Cognitive ability
Demographics
Demography
Epidemiology
Female
Heterogeneity
Humans
Incidence
Infectious Diseases
Male
Medicine
Medicine & Public Health
Meta-analysis
Neurodegenerative diseases
Oncology
Prevalence
Public Health
Regression analysis
Review
Risk Factors
Subgroups
Systematic review
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Description
Summary:As China faces demographic shifts and socioeconomic changes, the burden of Alzheimer’s disease (AD) and associated cognitive impairments is increasing dramatically, with significant implications for public health and the economy. This systematic review and meta-analysis aims to provide a comprehensive assessment of the prevalence and incidence of AD across China. Drawing from an extensive search of international and Chinese databases up to August 27, 2023, including PubMed, Embase, and the Cochrane Library, we synthesized data from 105 studies. Our analysis reveals a combined prevalence of AD of 3.48% within a sample of 626,276 elderly individuals and an incidence rate of 7.90 per 1000 person-years. Subgroup and meta-regression analyses highlight age and gender as pivotal factors influencing these epidemiological patterns. Notably, significant heterogeneity exists due to variations in diagnostic criteria and study quality, impacting the comparability of findings. This meta-analysis underscores the need for continued research into demographic and modifiable risk factors influencing AD, while emphasizing standardized reporting practices to address these limitations and improve the understanding of AD’s challenge in China.
ISSN:0393-2990
1573-7284
1573-7284
DOI:10.1007/s10654-024-01144-2