Outcomes following heart valve surgery in patients with infective endocarditis and preoperative septic cerebral embolism: insights from the CAMPAIGN study group

• Published in: European journal of cardio-thoracic surgery 2024-08, Vol.66 (2)
• Main Authors: Marin-Cuartas, Mateo, De La Cuesta, Manuela, Weber, Carolyn, Krinke, Elisabeth, Lichtenberg, Artur, Petrov, Asen, Hagl, Christian, Aubin, Hug, Matschke, Klaus, Diab, Mahmoud, Luehr, Maximilian, Akhyari, Payam, Schnackenburg, Philipp, Tugtekin, Sems-Malte, Saha, Shekhar, Doenst, Torsten, Wahlers, Thorsten, Borger, Michael A, Misfeld, Martin
• Format: Article
• Language: English
• ISSN: 1873-734X; 1873-734X
• DOI: 10.1093/ejcts/ezae295

Abstract OBJECTIVES This study aimed to analyse the impact of preoperative septic cerebral embolism on early and late postoperative outcomes in patients with infective endocarditis undergoing valve surgery. METHODS Retrospective multicentric study based on the Clinical Multicentric Project for Analysis of Infective Endocarditis in Germany (CAMPAIGN) registry comprising patients with infective endocarditis who underwent valve surgery between 1994 and 2018 at 6 German centres. Patients were divided into 2 groups for statistical comparison according to the presence or absence of preoperative septic cerebral embolism. Propensity score matching was performed for adjusted comparisons of postoperative outcomes. Primary outcomes were 30-day mortality and estimated 5-year survival. RESULTS A total of 4917 patients were included in the analysis, 3909 (79.5%) patients without and 1008 (20.5%) patients with preoperative septic cerebral embolism. Patients with preoperative septic cerebral embolism had more baseline comorbidities. Mitral valve endocarditis (44.1% vs 33.0% P 10 mm (43.1% vs 30.0%, P