Chronic Cannabis users exhibit altered oscillatory dynamics and functional connectivity serving visuospatial processing

• Published in: Journal of psychopharmacology (Oxford) 2024-08, Vol.38 (8), p.724-734
• Main Authors: Castelblanco, Camilo A, Springer, Seth D, Schantell, Mikki, John, Jason A, Coutant, Anna T, Horne, Lucy K, Glesinger, Ryan, Eastman, Jacob A, Wilson, Tony W
• Format: Article
• Language: English
• Subjects: Adult; Attention; Attention - drug effects; Attention - physiology; Brain - drug effects; Brain - physiopathology; Cannabis; Cerebellum; Cognition - drug effects; Cognition - physiology; Cognitive ability; Drug abuse; Female; Humans; Information processing; Magnetoencephalography; Male; Marijuana; Neural networks; Theta rhythms; Visual perception; Visual Perception - drug effects; Visual Perception - physiology; Young Adult
• ISSN: 0269-8811; 1461-7285; 1461-7285
• DOI: 10.1177/02698811241265764

Background: Cannabis is the most widely used psychoactive drug in the United States. While multiple studies have associated acute cannabis consumption with alterations in cognitive function (e.g., visual and spatial attention), far less is known regarding the effects of chronic consumption on the neural dynamics supporting these cognitive functions. Methods: We used magnetoencephalography (MEG) and an established visuospatial processing task to elicit multi-spectral neuronal responses in 44 regular cannabis users and 53 demographically matched non-user controls. To examine the effects of chronic cannabis use on the oscillatory dynamics underlying visuospatial processing, neural responses were imaged using a time-frequency resolved beamformer and compared across groups. Results: Neuronal oscillations serving visuospatial processing were identified in the theta (4–8 Hz), alpha (8–14 Hz), and gamma range (56–76 Hz), and these were imaged and examined for group differences. Our key results indicated that users exhibited weaker theta oscillations in occipital and cerebellar regions and weaker gamma responses in the left temporal cortices compared to non-users. Lastly, alpha oscillations did not differ, but alpha connectivity among higher-order attention areas was weaker in cannabis users relative to non-users and correlated with performance. Conclusions: Overall, these results suggest that chronic cannabis users have alterations in the oscillatory dynamics and neural connectivity serving visuospatial attention. Such alterations were observed across multiple cortical areas critical for higher-order processing and may reflect compensatory activity and/or the initial emergence of aberrant dynamics. Future work is needed to fully understand the implications of altered multispectral oscillations and neural connectivity in cannabis users.