Clinically relevant differences between primary Raynaud's phenomenon and secondary to connective tissue disease

• Published in: Seminars in arthritis and rheumatism 2024-10, Vol.68, p.152521, Article 152521
• Main Authors: Di Donato, Stefano, Huang, Suiyuan, Pauling, John D, Del Galdo, Francesco, Sabbagh, Maya, Khanna, Dinesh, Hughes, Michael
• Format: Article
• Language: English
• Subjects: Adult; Aged; Clinical trials; Connective tissue disease; Connective Tissue Diseases - complications; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Outcome measures; Primary raynaud's; Raynaud Disease; Raynaud's phenomenon; Scleroderma; Scleroderma, Systemic - complications; Scleroderma, Systemic - physiopathology; Secondary raynaud's; Surveys and Questionnaires; Systemic sclerosis
• ISSN: 0049-0172; 1532-866X; 1532-866X
• DOI: 10.1016/j.semarthrit.2024.152521

Raynaud's phenomenon (RP) is a symptom complex associated with digital vascular compromise. Our aim was to examine for clinically relevant differences between primary RP (PRP) and secondary RP (SRP) to connective tissue disease. We report cross-sectional results from the Patient Survey of experiences of Raynaud's Phenomenon (PASRAP), which aimed to explore the broad-ranging impact of RP. The survey was widely distributed online including via social medial. Participation was voluntary and responses were anonymous. 1229 respondents completed PASRAP with self-reported RP: PRP 218 (17.7 %) and SRP 1011 (82.3 %) of which 903 (92.9 %) Systemic Sclerosis. The mean (SD) age was significantly lower in respondents with PRP (41.7 [11.8] vs 54.2 [12.4] years, P