Loading…
Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease
Background: The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent. Objective: To explore whether the association between AD pathology and cognition can be moderated by frailty. Methods: We included 1711 participants from the Alzheimer’s Disease...
Saved in:
| Published in: | Journal of Alzheimer's disease 2024-01, Vol.100 (4), p.1333-1343 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c236t-39bf9843d951bef3497c70d9a50342f21dff0a856c47853ba58f5aba6d5c15283 |
| container_end_page | 1343 |
| container_issue | 4 |
| container_start_page | 1333 |
| container_title | Journal of Alzheimer's disease |
| container_volume | 100 |
| creator | Han, Bao-Lin Ma, Ling-Zhi Han, Shuang-Ling Mi, Yin-Chu Liu, Jia-Yao Sheng, Ze-Hu Wang, Hui-Fu Tan, Lan |
| description | Background:
The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent.
Objective:
To explore whether the association between AD pathology and cognition can be moderated by frailty.
Methods:
We included 1711 participants from the Alzheimer’s Disease Neuroimaging Initiative database. Levels of cerebrospinal fluid amyloid-β, p-tau, and t-tau were identified for AD-related pathology based on the amyloid-β/tau/neurodegeneration (AT[N]) framework. Frailty was measured using a modified Frailty Index-11 (mFI-11). Regression and interaction models were utilized to assess the relationship among frailty, AT(N) profiles, and cognition. Moderation models analyzed the correlation between AT(N) profiles and cognition across three frailty levels. All analyses were corrected for age, sex, education, and APOE ɛ4 status.
Results:
In this study, frailty (odds ratio [OR] = 1.71, p |
| doi_str_mv | 10.3233/JAD-231489 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3087357607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3233_JAD-231489</sage_id><sourcerecordid>3092348161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c236t-39bf9843d951bef3497c70d9a50342f21dff0a856c47853ba58f5aba6d5c15283</originalsourceid><addsrcrecordid>eNpt0dtqFTEUBuAgij154wNIwAvbwrTJrMkkudzdPaiUVqReD5mZlTZl9mSbZGgrCH0NX88nMe2uCuJVAvnWnwU_Ia8524MSYP_j7LAogVdKPyPrXElRKM3U83wHJYtSSblGNmK8ZowB0_IlWQPNNDDJ1sn3o9vl4APSdIX0sx-QekuPg3FDuqMmUkPnfkzBtVPygSb_6GYx-s6Z5PxIDzDdII50drF9tkM_BW_dgHlu7PPk5egekcvvw7crdAsMP-9_RHroIpqIW-SFNUPEV0_nJvlyfHQxf1-cnp98mM9Oi66EOhWgW6tVBb0WvEULlZadZL02gkFV2pL31jKjRN1VUglojVBWmNbUvei4KBVsku1V7jL4rxPG1Cxc7HAYzIh-ig0wJUHImslM3_5Dr_0UxrxdVrqESvGaZ7W7Ul3wMQa0zTK4hQl3DWfNQylNLqVZlZLxm6fIqV1g_4f-biGDdysQzSX-_e8_Ub8ATcGSzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3092348161</pqid></control><display><type>article</type><title>Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease</title><source>SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)</source><creator>Han, Bao-Lin ; Ma, Ling-Zhi ; Han, Shuang-Ling ; Mi, Yin-Chu ; Liu, Jia-Yao ; Sheng, Ze-Hu ; Wang, Hui-Fu ; Tan, Lan</creator><contributor>Liu, Yong</contributor><creatorcontrib>Han, Bao-Lin ; Ma, Ling-Zhi ; Han, Shuang-Ling ; Mi, Yin-Chu ; Liu, Jia-Yao ; Sheng, Ze-Hu ; Wang, Hui-Fu ; Tan, Lan ; Alzheimer’s Disease Neuroimaging Initiative ; for the Alzheimer’s Disease Neuroimaging Initiative ; Liu, Yong</creatorcontrib><description>Background:
The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent.
Objective:
To explore whether the association between AD pathology and cognition can be moderated by frailty.
Methods:
We included 1711 participants from the Alzheimer’s Disease Neuroimaging Initiative database. Levels of cerebrospinal fluid amyloid-β, p-tau, and t-tau were identified for AD-related pathology based on the amyloid-β/tau/neurodegeneration (AT[N]) framework. Frailty was measured using a modified Frailty Index-11 (mFI-11). Regression and interaction models were utilized to assess the relationship among frailty, AT(N) profiles, and cognition. Moderation models analyzed the correlation between AT(N) profiles and cognition across three frailty levels. All analyses were corrected for age, sex, education, and APOE ɛ4 status.
Results:
In this study, frailty (odds ratio [OR] = 1.71, p < 0.001) and AT(N) profiles (OR = 2.00, p < 0.001) were independently associated with cognitive status. The model fit was improved when frailty was added to the model examining the relationship between AT(N) profiles and cognition (p < 0.001). There was a significant interaction between frailty and AT(N) profiles in relation to cognitive status (OR = 1.12, pinteraction = 0.028). Comparable results were obtained when Mini-Mental State Examination scores were utilized as the measure of cognitive performance. The association between AT(N) profiles and cognition was stronger with the levels of frailty.
Conclusions:
Frailty may diminish patients’ resilience to AD pathology and accelerate cognitive decline resulting from abnormal AD-related pathology. In summary, frailty contributes to elucidating the relationship between AD-related pathology and cognitive impairment.</description><identifier>ISSN: 1387-2877</identifier><identifier>ISSN: 1875-8908</identifier><identifier>EISSN: 1875-8908</identifier><identifier>DOI: 10.3233/JAD-231489</identifier><identifier>PMID: 39093070</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - complications ; Alzheimer Disease - psychology ; Alzheimer's disease ; Amyloid beta-Peptides - cerebrospinal fluid ; Apolipoprotein E ; Cerebrospinal fluid ; Cognition ; Cognition & reasoning ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - cerebrospinal fluid ; Cognitive Dysfunction - psychology ; Cognitive tasks ; Female ; Frailty ; Frailty - complications ; Frailty - psychology ; Humans ; Interaction models ; Male ; Medical imaging ; Neurodegenerative diseases ; Neuroimaging ; Neuropsychological Tests ; Pathology ; Regression analysis ; Tau protein ; tau Proteins - cerebrospinal fluid ; β-Amyloid</subject><ispartof>Journal of Alzheimer's disease, 2024-01, Vol.100 (4), p.1333-1343</ispartof><rights>2024 – IOS Press. All rights reserved</rights><rights>Copyright IOS Press BV 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c236t-39bf9843d951bef3497c70d9a50342f21dff0a856c47853ba58f5aba6d5c15283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39093070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Liu, Yong</contributor><creatorcontrib>Han, Bao-Lin</creatorcontrib><creatorcontrib>Ma, Ling-Zhi</creatorcontrib><creatorcontrib>Han, Shuang-Ling</creatorcontrib><creatorcontrib>Mi, Yin-Chu</creatorcontrib><creatorcontrib>Liu, Jia-Yao</creatorcontrib><creatorcontrib>Sheng, Ze-Hu</creatorcontrib><creatorcontrib>Wang, Hui-Fu</creatorcontrib><creatorcontrib>Tan, Lan</creatorcontrib><creatorcontrib>Alzheimer’s Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>for the Alzheimer’s Disease Neuroimaging Initiative</creatorcontrib><title>Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease</title><title>Journal of Alzheimer's disease</title><addtitle>J Alzheimers Dis</addtitle><description>Background:
The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent.
Objective:
To explore whether the association between AD pathology and cognition can be moderated by frailty.
Methods:
We included 1711 participants from the Alzheimer’s Disease Neuroimaging Initiative database. Levels of cerebrospinal fluid amyloid-β, p-tau, and t-tau were identified for AD-related pathology based on the amyloid-β/tau/neurodegeneration (AT[N]) framework. Frailty was measured using a modified Frailty Index-11 (mFI-11). Regression and interaction models were utilized to assess the relationship among frailty, AT(N) profiles, and cognition. Moderation models analyzed the correlation between AT(N) profiles and cognition across three frailty levels. All analyses were corrected for age, sex, education, and APOE ɛ4 status.
Results:
In this study, frailty (odds ratio [OR] = 1.71, p < 0.001) and AT(N) profiles (OR = 2.00, p < 0.001) were independently associated with cognitive status. The model fit was improved when frailty was added to the model examining the relationship between AT(N) profiles and cognition (p < 0.001). There was a significant interaction between frailty and AT(N) profiles in relation to cognitive status (OR = 1.12, pinteraction = 0.028). Comparable results were obtained when Mini-Mental State Examination scores were utilized as the measure of cognitive performance. The association between AT(N) profiles and cognition was stronger with the levels of frailty.
Conclusions:
Frailty may diminish patients’ resilience to AD pathology and accelerate cognitive decline resulting from abnormal AD-related pathology. In summary, frailty contributes to elucidating the relationship between AD-related pathology and cognitive impairment.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - cerebrospinal fluid</subject><subject>Apolipoprotein E</subject><subject>Cerebrospinal fluid</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - cerebrospinal fluid</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Cognitive tasks</subject><subject>Female</subject><subject>Frailty</subject><subject>Frailty - complications</subject><subject>Frailty - psychology</subject><subject>Humans</subject><subject>Interaction models</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Neuropsychological Tests</subject><subject>Pathology</subject><subject>Regression analysis</subject><subject>Tau protein</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>β-Amyloid</subject><issn>1387-2877</issn><issn>1875-8908</issn><issn>1875-8908</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpt0dtqFTEUBuAgij154wNIwAvbwrTJrMkkudzdPaiUVqReD5mZlTZl9mSbZGgrCH0NX88nMe2uCuJVAvnWnwU_Ia8524MSYP_j7LAogVdKPyPrXElRKM3U83wHJYtSSblGNmK8ZowB0_IlWQPNNDDJ1sn3o9vl4APSdIX0sx-QekuPg3FDuqMmUkPnfkzBtVPygSb_6GYx-s6Z5PxIDzDdII50drF9tkM_BW_dgHlu7PPk5egekcvvw7crdAsMP-9_RHroIpqIW-SFNUPEV0_nJvlyfHQxf1-cnp98mM9Oi66EOhWgW6tVBb0WvEULlZadZL02gkFV2pL31jKjRN1VUglojVBWmNbUvei4KBVsku1V7jL4rxPG1Cxc7HAYzIh-ig0wJUHImslM3_5Dr_0UxrxdVrqESvGaZ7W7Ul3wMQa0zTK4hQl3DWfNQylNLqVZlZLxm6fIqV1g_4f-biGDdysQzSX-_e8_Ub8ATcGSzw</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Han, Bao-Lin</creator><creator>Ma, Ling-Zhi</creator><creator>Han, Shuang-Ling</creator><creator>Mi, Yin-Chu</creator><creator>Liu, Jia-Yao</creator><creator>Sheng, Ze-Hu</creator><creator>Wang, Hui-Fu</creator><creator>Tan, Lan</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease</title><author>Han, Bao-Lin ; Ma, Ling-Zhi ; Han, Shuang-Ling ; Mi, Yin-Chu ; Liu, Jia-Yao ; Sheng, Ze-Hu ; Wang, Hui-Fu ; Tan, Lan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c236t-39bf9843d951bef3497c70d9a50342f21dff0a856c47853ba58f5aba6d5c15283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - cerebrospinal fluid</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - cerebrospinal fluid</topic><topic>Apolipoprotein E</topic><topic>Cerebrospinal fluid</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - cerebrospinal fluid</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Cognitive tasks</topic><topic>Female</topic><topic>Frailty</topic><topic>Frailty - complications</topic><topic>Frailty - psychology</topic><topic>Humans</topic><topic>Interaction models</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Neuropsychological Tests</topic><topic>Pathology</topic><topic>Regression analysis</topic><topic>Tau protein</topic><topic>tau Proteins - cerebrospinal fluid</topic><topic>β-Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Bao-Lin</creatorcontrib><creatorcontrib>Ma, Ling-Zhi</creatorcontrib><creatorcontrib>Han, Shuang-Ling</creatorcontrib><creatorcontrib>Mi, Yin-Chu</creatorcontrib><creatorcontrib>Liu, Jia-Yao</creatorcontrib><creatorcontrib>Sheng, Ze-Hu</creatorcontrib><creatorcontrib>Wang, Hui-Fu</creatorcontrib><creatorcontrib>Tan, Lan</creatorcontrib><creatorcontrib>Alzheimer’s Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>for the Alzheimer’s Disease Neuroimaging Initiative</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Alzheimer's disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Bao-Lin</au><au>Ma, Ling-Zhi</au><au>Han, Shuang-Ling</au><au>Mi, Yin-Chu</au><au>Liu, Jia-Yao</au><au>Sheng, Ze-Hu</au><au>Wang, Hui-Fu</au><au>Tan, Lan</au><au>Liu, Yong</au><aucorp>Alzheimer’s Disease Neuroimaging Initiative</aucorp><aucorp>for the Alzheimer’s Disease Neuroimaging Initiative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease</atitle><jtitle>Journal of Alzheimer's disease</jtitle><addtitle>J Alzheimers Dis</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>100</volume><issue>4</issue><spage>1333</spage><epage>1343</epage><pages>1333-1343</pages><issn>1387-2877</issn><issn>1875-8908</issn><eissn>1875-8908</eissn><abstract>Background:
The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent.
Objective:
To explore whether the association between AD pathology and cognition can be moderated by frailty.
Methods:
We included 1711 participants from the Alzheimer’s Disease Neuroimaging Initiative database. Levels of cerebrospinal fluid amyloid-β, p-tau, and t-tau were identified for AD-related pathology based on the amyloid-β/tau/neurodegeneration (AT[N]) framework. Frailty was measured using a modified Frailty Index-11 (mFI-11). Regression and interaction models were utilized to assess the relationship among frailty, AT(N) profiles, and cognition. Moderation models analyzed the correlation between AT(N) profiles and cognition across three frailty levels. All analyses were corrected for age, sex, education, and APOE ɛ4 status.
Results:
In this study, frailty (odds ratio [OR] = 1.71, p < 0.001) and AT(N) profiles (OR = 2.00, p < 0.001) were independently associated with cognitive status. The model fit was improved when frailty was added to the model examining the relationship between AT(N) profiles and cognition (p < 0.001). There was a significant interaction between frailty and AT(N) profiles in relation to cognitive status (OR = 1.12, pinteraction = 0.028). Comparable results were obtained when Mini-Mental State Examination scores were utilized as the measure of cognitive performance. The association between AT(N) profiles and cognition was stronger with the levels of frailty.
Conclusions:
Frailty may diminish patients’ resilience to AD pathology and accelerate cognitive decline resulting from abnormal AD-related pathology. In summary, frailty contributes to elucidating the relationship between AD-related pathology and cognitive impairment.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>39093070</pmid><doi>10.3233/JAD-231489</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1387-2877 |
| ispartof | Journal of Alzheimer's disease, 2024-01, Vol.100 (4), p.1333-1343 |
| issn | 1387-2877 1875-8908 1875-8908 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3087357607 |
| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - complications Alzheimer Disease - psychology Alzheimer's disease Amyloid beta-Peptides - cerebrospinal fluid Apolipoprotein E Cerebrospinal fluid Cognition Cognition & reasoning Cognition - physiology Cognitive ability Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - psychology Cognitive tasks Female Frailty Frailty - complications Frailty - psychology Humans Interaction models Male Medical imaging Neurodegenerative diseases Neuroimaging Neuropsychological Tests Pathology Regression analysis Tau protein tau Proteins - cerebrospinal fluid β-Amyloid |
| title | Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T04%3A07%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Explore%20the%20Role%20of%20Frailty%20as%20a%20Contributor%20to%20the%20Association%20Between%20AT(N)%20Profiles%20and%20Cognition%20in%20Alzheimer%E2%80%99s%20Disease&rft.jtitle=Journal%20of%20Alzheimer's%20disease&rft.au=Han,%20Bao-Lin&rft.aucorp=Alzheimer%E2%80%99s%20Disease%20Neuroimaging%20Initiative&rft.date=2024-01-01&rft.volume=100&rft.issue=4&rft.spage=1333&rft.epage=1343&rft.pages=1333-1343&rft.issn=1387-2877&rft.eissn=1875-8908&rft_id=info:doi/10.3233/JAD-231489&rft_dat=%3Cproquest_cross%3E3092348161%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c236t-39bf9843d951bef3497c70d9a50342f21dff0a856c47853ba58f5aba6d5c15283%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3092348161&rft_id=info:pmid/39093070&rft_sage_id=10.3233_JAD-231489&rfr_iscdi=true |