Glass ionomer cement particles pre-reacted with chlorhexidine: Physical/chemical properties and antimicrobial activity

• Published in: Journal of the mechanical behavior of biomedical materials 2024-10, Vol.158, p.106678, Article 106678
• Main Authors: Gomes, Felipe Silva, Campos-Ferreira, Paulo Vitor, Macedo, Rayssa Ferreira Cavaleiro de, Costa-Oliveira, Bárbara Emanoele, Bauer, Jose
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibacterial activity; Chemical Phenomena; Chlorhexidine; Chlorhexidine - chemistry; Chlorhexidine - pharmacology; Glass ionomer cement; Glass Ionomer Cements - chemistry; Glass Ionomer Cements - pharmacology; Hardness; Ion release; Materials Testing; Mechanical Phenomena; Mechanical properties; Streptococcus mutans - drug effects; Surface Properties
• ISSN: 1751-6161; 1878-0180; 1878-0180
• DOI: 10.1016/j.jmbbm.2024.106678

Analyze the effects of the functionalization of pre-functionalized GIC particles with chlorhexidine on the physicochemical properties and antimicrobial activity. Four groups were prepared: (1) GIC (Bioglass R - Biodinamica) - control group; (2) GIC-CHX 1%: Group containing 1% pre-reacted CHX particles; (3) GIC-CHX 2.5%: Group containing 2.5% pre-reacted CHX particles; (4) GIC-CHX 5%: Group containing 5% pre-reacted CHX particles. Hourglass-shaped specimens (10 mm × 2 mm x 1 mm) were fabricated for mechanical tests including cohesive strength (n = 12), modulus of elasticity (n = 12) and microhardness (n = 10). Discs (10 mm × 2 mm) were prepared for the analysis of Ca+2, PO4− and F− ions release (n = 3), and roughness (n = 12). To evaluate the setting time, a Gilmore needle was used according to ISO 9917–1:2016. Disk-shaped specimens (5 × 1mm) were manufactured and subjected to bacterial activity (n = 9) (Streptococcus mutans ATCC 159). Modulus, roughness, setting time and ions release (Ca+2, PO4−, and F−) there were no statistically significant differences among the groups (p > 0.05). The setting time did not change with the incorporation of CHX. The GIC-CHX 2.5% and GIC-CHX 5% groups exhibited superior antibacterial activity compared to the control group and GIC-CHX 1% (p