Association of Dopamine pathway gene polymorphisms in patients with alcohol dependence

•Significant genotype and allelic differences in DRD1 rs686 and COMT rs4680 between cases and controls.•Significant association of DRD1 rs4532 and DRD2 rs6275 AA genotype with early onset of alcohol use and severity of AD respectively.•Linkage disequilibrium between markers DRD1 rs686 - rs4532 showi...

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Bibliographic Details
Published in:Asian journal of psychiatry 2024-10, Vol.100, p.104166, Article 104166
Main Authors: Singh, Renu, Grover, Tripti, Ambekar, Atul, Gupta, Ranjan, Jain, Raka, Vaswani, Meera, Mishra, Ashwani, Sharma, Arundhati
Format: Article
Language:English
Subjects:
Adult
Alcoholism - genetics
Dopamine - metabolism
Female
Genetic Predisposition to Disease - genetics
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Dopamine D1 - genetics
Receptors, Dopamine D2 - genetics
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Summary:•Significant genotype and allelic differences in DRD1 rs686 and COMT rs4680 between cases and controls.•Significant association of DRD1 rs4532 and DRD2 rs6275 AA genotype with early onset of alcohol use and severity of AD respectively.•Linkage disequilibrium between markers DRD1 rs686 - rs4532 showing a significant protective effect of rs686 G and rs4532 T haplotype.
ISSN:1876-2018
1876-2026
1876-2026
DOI:10.1016/j.ajp.2024.104166