A novel treatment strategy targeting cellular pathways with natural products to alleviate sarcopenia

• Published in: Phytotherapy research 2024-11, Vol.38 (11), p.5033-5051
• Main Authors: Lee, Da Hee, Lee, Hye Jin, Yang, Gabsik, Kim, Dae Yong, Kim, Jong Uk, Yook, Tae Han, Lee, Jun Ho, Kim, Hong Jun
• Format: Article
• Language: English
• Subjects: Aging; Aging - drug effects; Animals; Biological Products - pharmacology; Biological Products - therapeutic use; Body fat; Cachexia; clinical trials; Diabetes mellitus; Exercise; Geriatrics; Humans; muscle atrophy; Muscle, Skeletal - drug effects; Muscles; Myostatin; Natural products; Nutrient deficiency; Older people; Pathogenesis; Physical activity; Protein biosynthesis; Protein synthesis; Proteins; Quality of Life; Sarcopenia; Sarcopenia - drug therapy; Steroid hormones
• ISSN: 0951-418X; 1099-1573; 1099-1573
• DOI: 10.1002/ptr.8301

Sarcopenia is a condition marked by a significant reduction in muscle mass and strength, primarily due to the aging process, which critically impacts muscle protein dynamics, metabolic functions, and overall physical functionality. This condition leads to increased body fat and reduced daily activity, contributing to severe health issues and a lower quality of life among the elderly. Recognized in the ICD‐10‐CM only in 2016, sarcopenia lacks definitive treatment options despite its growing prevalence and substantial social and economic implications. Given the aging global population, addressing sarcopenia has become increasingly relevant and necessary. The primary causes include aging, cachexia, diabetes, and nutritional deficiencies, leading to imbalances in protein synthesis and degradation, mitochondrial dysfunction, and hormonal changes. Exercise remains the most effective intervention, but it is often impractical for individuals with limited mobility, and pharmacological options such as anabolic steroids and myostatin inhibitors are not FDA‐approved and are still under investigation. This review is crucial as it examines the potential of natural products as a novel treatment strategy for sarcopenia, targeting multiple mechanisms involved in its pathogenesis. By exploring natural products' multi‐targeted effects, this study aims to provide innovative and practical solutions for sarcopenia management. Therefore, this review indicates significant improvements in muscle mass and function with the use of specific natural compounds, suggesting promising alternatives for those unable to engage in regular physical activity. Schematic overview of the possible therapeutic mechanisms involved in sarcopenia with various natural products. The global rise in aging populations has led to an increased prevalence of sarcopenia, which is becoming a new social issue. Currently, there is no FDA‐approved treatment for sarcopenia; however, ongoing studies are identifying diverse factors and mechanisms involved in the condition to establish a definitive treatment protocol. Various natural products developed thus far exhibit significant potential in developing treatments by targeting these identified factors and mechanisms.