Neovaginoplasty With Nile Tilapia Skin Graft in A Patient With Gonadal Dysgenesis: A Case Report

Gonadal dysgenesis, a genetic condition characterized by incomplete of defective formation of the gonads, can present with vaginal agenesis in individuals with 46, XY karyotype. We report an innovative intervention in the management of vaginal agenesis in a 19-year-old female with gonadal dysgenesis...

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Bibliographic Details
Published in:Journal of pediatric & adolescent gynecology 2024-08
Main Authors: Coutinho, Samuel Soares, Braga, Luana Darc de Menezes, Costa, Mylena Evilyn Sousa, Veloso, Mariana Oliveira, Alves, Ana Paula Negreiros Nunes, Júnior, Edmar Maciel Lima, Bruno, Zenilda Vieira, Filho, Manoel Odorico de Moraes, Paier, Carlos Roberto Koscky, Rodrigues, Felipe Augusto Rocha, Bezerra, Leonardo Robson Pinheiro Sobreira
Format: Article
Language:English
Subjects:
Biocompatible materials
Gonadal dysgenesis
Vaginal agenesis
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Summary:Gonadal dysgenesis, a genetic condition characterized by incomplete of defective formation of the gonads, can present with vaginal agenesis in individuals with 46, XY karyotype. We report an innovative intervention in the management of vaginal agenesis in a 19-year-old female with gonadal dysgenesis. Despite initial attempts with vaginal dilators, the patient presented unresponsive, leading to the adoption of a neovaginoplasty using Nile Tilapia Fish Skin (NTFS) as graft. The procedure, based on the McIndoe technique, involved the creation of a 10 cm x 3 cm vaginal canal with an NTFS-wrapped acrylic mold without complications. The use of NTFS as a graft for neovaginoplasty in gonadal dysgenesis, a novel approach not previously reported in medical literature for this diagnosis, demonstrated favorable outcomes in terms of functionality and patient well-being.
ISSN:1083-3188
1873-4332
1873-4332
DOI:10.1016/j.jpag.2024.07.008