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Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis
Report the clinical findings, risk factors, treatment, and visual outcomes associated with endophthalmitis in comparison to culture-positive endophthalmitis associated with non- species. A retrospective chart review of adults between 18 and 89 years of age diagnosed with exogenous culture-positiv...
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| Published in: | Curēus (Palo Alto, CA) CA), 2024-08, Vol.16 (8), p.e65974 |
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| container_title | Curēus (Palo Alto, CA) |
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| creator | Woodward, Richmond De Luna, Regina Robbins, Cason B Feng, Henry L Stout, Jason E Fekrat, Sharon |
| description | Report the clinical findings, risk factors, treatment, and visual outcomes associated with
endophthalmitis in comparison to culture-positive endophthalmitis associated with non-
species.
A retrospective chart review of adults between 18 and 89 years of age diagnosed with exogenous culture-positive endophthalmitis between January 1, 2009, and January 1, 2018, at the Duke Eye Center (Durham, North Carolina) with at least six months of follow-up from time of initial diagnosis was conducted. Clinical data including patient demographics, ocular history, baseline corrected visual acuity (VA) prior to presentation, time to presentation, presenting exam findings, VA at presentation, presumed etiology of endophthalmitis, medical and surgical management, and VA at the six-month follow-up was extracted and statistically analyzed.
Fifty-six eyes from 56 patients with culture-positive endophthalmitis were identified. Eyes with
(n=18) had elevated intraocular pressure (IOP) at presentation (p=0.002), worse mean VA (Snellen) at presentation (20/14159 vs. 20/3098, p |
| doi_str_mv | 10.7759/cureus.65974 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3088558915</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3088558915</sourcerecordid><originalsourceid>FETCH-LOGICAL-c206t-7d68e06325da9f2be382e7bf0d439d9936dd77e0c45b1722cdd3ee1ed528b09f3</originalsourceid><addsrcrecordid>eNpdkUtLxDAUhYMoKurOtQTcuJhqHpMmWcrgC0QFH9uSJrdOpG1qki7891ZHRV3dA-fjcOFDaJ-SYymFPrFjhDEdl0LL-RraZrRUhaJqvv4rb6G9lF4IIZRIRiTZRFtcU0IU5dvo7S5Cgj77_hkvliYamyH6lL1NM_wQweRuamfY9A4_-TSaFt-O2YYOEvY9vs8RhhxssHZqFqEbTASHc8A3oS_-tme9C8MyL03b-ezTLtpoTJtg7-vuoMfzs4fFZXF9e3G1OL0uLCNlLqQrFZCSM-GMblgNXDGQdUPcnGunNS-dkxKInYuaSsascxyAghNM1UQ3fAcdrXaHGF5HSLnqfLLQtqaHMKaKE6WEUJqKCT38h76EMfbTdxOlNROKqXKiZivKxpBShKYaou9MfKsoqT6sVCsr1aeVCT_4Gh3rDtwP_O2AvwMeGYsH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3099258286</pqid></control><display><type>article</type><title>Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Woodward, Richmond ; De Luna, Regina ; Robbins, Cason B ; Feng, Henry L ; Stout, Jason E ; Fekrat, Sharon</creator><creatorcontrib>Woodward, Richmond ; De Luna, Regina ; Robbins, Cason B ; Feng, Henry L ; Stout, Jason E ; Fekrat, Sharon</creatorcontrib><description>Report the clinical findings, risk factors, treatment, and visual outcomes associated with
endophthalmitis in comparison to culture-positive endophthalmitis associated with non-
species.
A retrospective chart review of adults between 18 and 89 years of age diagnosed with exogenous culture-positive endophthalmitis between January 1, 2009, and January 1, 2018, at the Duke Eye Center (Durham, North Carolina) with at least six months of follow-up from time of initial diagnosis was conducted. Clinical data including patient demographics, ocular history, baseline corrected visual acuity (VA) prior to presentation, time to presentation, presenting exam findings, VA at presentation, presumed etiology of endophthalmitis, medical and surgical management, and VA at the six-month follow-up was extracted and statistically analyzed.
Fifty-six eyes from 56 patients with culture-positive endophthalmitis were identified. Eyes with
(n=18) had elevated intraocular pressure (IOP) at presentation (p=0.002), worse mean VA (Snellen) at presentation (20/14159 vs. 20/3098, p<0.001), and worse mean VA (Snellen) at six months (20/3475 vs. 20/235, p<0.001) compared to non-
cases (n=38). Time to presentation (days) (median, IQR) was longer in eyes that underwent glaucoma surgery for both
(2241 (836, 3709) vs. 3 (2, 31), p=0.003) and non-
endophthalmitis (1236 (125, 3582) vs. 6 (4, 25), p<0.0001). There was no difference in VA at six months between
and non-
eyes based on treatment. Conclusions:
are rare but important causes of exogenous endophthalmitis, and in our study, they were associated with worse visual outcomes than non-
. A history of any glaucoma surgery, even procedures performed years earlier, should be elicited when evaluating patients with ocular symptoms.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.65974</identifier><identifier>PMID: 39100813</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Bacteria ; Cataracts ; Chi-square test ; Cornea ; Etiology ; Eye surgery ; Glaucoma ; Patients ; Statistical analysis ; Streptococcus infections ; Trauma ; Ulcers ; Visual acuity</subject><ispartof>Curēus (Palo Alto, CA), 2024-08, Vol.16 (8), p.e65974</ispartof><rights>Copyright © 2024, Woodward et al.</rights><rights>Copyright © 2024, Woodward et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c206t-7d68e06325da9f2be382e7bf0d439d9936dd77e0c45b1722cdd3ee1ed528b09f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3099258286/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3099258286?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25731,27901,27902,36989,36990,44566,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39100813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woodward, Richmond</creatorcontrib><creatorcontrib>De Luna, Regina</creatorcontrib><creatorcontrib>Robbins, Cason B</creatorcontrib><creatorcontrib>Feng, Henry L</creatorcontrib><creatorcontrib>Stout, Jason E</creatorcontrib><creatorcontrib>Fekrat, Sharon</creatorcontrib><title>Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Report the clinical findings, risk factors, treatment, and visual outcomes associated with
endophthalmitis in comparison to culture-positive endophthalmitis associated with non-
species.
A retrospective chart review of adults between 18 and 89 years of age diagnosed with exogenous culture-positive endophthalmitis between January 1, 2009, and January 1, 2018, at the Duke Eye Center (Durham, North Carolina) with at least six months of follow-up from time of initial diagnosis was conducted. Clinical data including patient demographics, ocular history, baseline corrected visual acuity (VA) prior to presentation, time to presentation, presenting exam findings, VA at presentation, presumed etiology of endophthalmitis, medical and surgical management, and VA at the six-month follow-up was extracted and statistically analyzed.
Fifty-six eyes from 56 patients with culture-positive endophthalmitis were identified. Eyes with
(n=18) had elevated intraocular pressure (IOP) at presentation (p=0.002), worse mean VA (Snellen) at presentation (20/14159 vs. 20/3098, p<0.001), and worse mean VA (Snellen) at six months (20/3475 vs. 20/235, p<0.001) compared to non-
cases (n=38). Time to presentation (days) (median, IQR) was longer in eyes that underwent glaucoma surgery for both
(2241 (836, 3709) vs. 3 (2, 31), p=0.003) and non-
endophthalmitis (1236 (125, 3582) vs. 6 (4, 25), p<0.0001). There was no difference in VA at six months between
and non-
eyes based on treatment. Conclusions:
are rare but important causes of exogenous endophthalmitis, and in our study, they were associated with worse visual outcomes than non-
. A history of any glaucoma surgery, even procedures performed years earlier, should be elicited when evaluating patients with ocular symptoms.</description><subject>Bacteria</subject><subject>Cataracts</subject><subject>Chi-square test</subject><subject>Cornea</subject><subject>Etiology</subject><subject>Eye surgery</subject><subject>Glaucoma</subject><subject>Patients</subject><subject>Statistical analysis</subject><subject>Streptococcus infections</subject><subject>Trauma</subject><subject>Ulcers</subject><subject>Visual acuity</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkUtLxDAUhYMoKurOtQTcuJhqHpMmWcrgC0QFH9uSJrdOpG1qki7891ZHRV3dA-fjcOFDaJ-SYymFPrFjhDEdl0LL-RraZrRUhaJqvv4rb6G9lF4IIZRIRiTZRFtcU0IU5dvo7S5Cgj77_hkvliYamyH6lL1NM_wQweRuamfY9A4_-TSaFt-O2YYOEvY9vs8RhhxssHZqFqEbTASHc8A3oS_-tme9C8MyL03b-ezTLtpoTJtg7-vuoMfzs4fFZXF9e3G1OL0uLCNlLqQrFZCSM-GMblgNXDGQdUPcnGunNS-dkxKInYuaSsascxyAghNM1UQ3fAcdrXaHGF5HSLnqfLLQtqaHMKaKE6WEUJqKCT38h76EMfbTdxOlNROKqXKiZivKxpBShKYaou9MfKsoqT6sVCsr1aeVCT_4Gh3rDtwP_O2AvwMeGYsH</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Woodward, Richmond</creator><creator>De Luna, Regina</creator><creator>Robbins, Cason B</creator><creator>Feng, Henry L</creator><creator>Stout, Jason E</creator><creator>Fekrat, Sharon</creator><general>Cureus Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20240801</creationdate><title>Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis</title><author>Woodward, Richmond ; De Luna, Regina ; Robbins, Cason B ; Feng, Henry L ; Stout, Jason E ; Fekrat, Sharon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c206t-7d68e06325da9f2be382e7bf0d439d9936dd77e0c45b1722cdd3ee1ed528b09f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bacteria</topic><topic>Cataracts</topic><topic>Chi-square test</topic><topic>Cornea</topic><topic>Etiology</topic><topic>Eye surgery</topic><topic>Glaucoma</topic><topic>Patients</topic><topic>Statistical analysis</topic><topic>Streptococcus infections</topic><topic>Trauma</topic><topic>Ulcers</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woodward, Richmond</creatorcontrib><creatorcontrib>De Luna, Regina</creatorcontrib><creatorcontrib>Robbins, Cason B</creatorcontrib><creatorcontrib>Feng, Henry L</creatorcontrib><creatorcontrib>Stout, Jason E</creatorcontrib><creatorcontrib>Fekrat, Sharon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woodward, Richmond</au><au>De Luna, Regina</au><au>Robbins, Cason B</au><au>Feng, Henry L</au><au>Stout, Jason E</au><au>Fekrat, Sharon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>16</volume><issue>8</issue><spage>e65974</spage><pages>e65974-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Report the clinical findings, risk factors, treatment, and visual outcomes associated with
endophthalmitis in comparison to culture-positive endophthalmitis associated with non-
species.
A retrospective chart review of adults between 18 and 89 years of age diagnosed with exogenous culture-positive endophthalmitis between January 1, 2009, and January 1, 2018, at the Duke Eye Center (Durham, North Carolina) with at least six months of follow-up from time of initial diagnosis was conducted. Clinical data including patient demographics, ocular history, baseline corrected visual acuity (VA) prior to presentation, time to presentation, presenting exam findings, VA at presentation, presumed etiology of endophthalmitis, medical and surgical management, and VA at the six-month follow-up was extracted and statistically analyzed.
Fifty-six eyes from 56 patients with culture-positive endophthalmitis were identified. Eyes with
(n=18) had elevated intraocular pressure (IOP) at presentation (p=0.002), worse mean VA (Snellen) at presentation (20/14159 vs. 20/3098, p<0.001), and worse mean VA (Snellen) at six months (20/3475 vs. 20/235, p<0.001) compared to non-
cases (n=38). Time to presentation (days) (median, IQR) was longer in eyes that underwent glaucoma surgery for both
(2241 (836, 3709) vs. 3 (2, 31), p=0.003) and non-
endophthalmitis (1236 (125, 3582) vs. 6 (4, 25), p<0.0001). There was no difference in VA at six months between
and non-
eyes based on treatment. Conclusions:
are rare but important causes of exogenous endophthalmitis, and in our study, they were associated with worse visual outcomes than non-
. A history of any glaucoma surgery, even procedures performed years earlier, should be elicited when evaluating patients with ocular symptoms.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>39100813</pmid><doi>10.7759/cureus.65974</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Bacteria Cataracts Chi-square test Cornea Etiology Eye surgery Glaucoma Patients Statistical analysis Streptococcus infections Trauma Ulcers Visual acuity |
| title | Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis |
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