Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS

HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and noncore subsets. Noncore permissive graft-versus-host mismatches show significantly reduced risks of relapse without increased nonrelapse mortality compared with allele-matched pair...

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Bibliographic Details
Published in:Blood 2024-10, Vol.144 (16), p.1747-1751
Main Authors: Arrieta-Bolaños, Esteban, van der Burg, Lars L. J., Gedde-Dahl, Tobias, Robin, Marie, Salmenniemi, Urpu, Kröger, Nicolaus, Yakoub-Agha, Ibrahim, Huynh, Anne, Crawley, Charles, Deconinck, Eric, Bulabois, Claude Eric, Forcade, Edouard, Tholouli, Eleni, van der Hem, Joost G. K., van Balen, Peter, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Malard, Florent, Ruggeri, Annalisa, Fleischhauer, Katharina
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Female
Graft vs Host Disease - immunology
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing - methods
HLA-DP Antigens - genetics
Humans
Leukemia - immunology
Male
Middle Aged
Myelodysplastic Syndromes - therapy
Citations: Items that this one cites
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Summary:HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and noncore subsets. Noncore permissive graft-versus-host mismatches show significantly reduced risks of relapse without increased nonrelapse mortality compared with allele-matched pairs.
ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood.2024024351