Diagnostic accuracy of an uncorrected native T1 mapping sequence for liver fibrosis and inflammation in autoimmune hepatitis: a prospective study using histopathology as reference standard

Purpose There is an unmet clinical need for non-invasive imaging biomarkers that could replace liver biopsy in the management of patients with autoimmune hepatitis (AIH). In this study, we sought to evaluate the diagnostic accuracy of a simple uncorrected, non-contrast T1 mapping for detecting fibro...

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Bibliographic Details
Published in:Radiologia medica 2024-10, Vol.129 (10), p.1431-1443
Main Authors: Gomes, Natália B. N., Torres, Ulysses S., Caiado, Angela H. M., Fucuta, Patricia S., Ferraz, Maria Lucia C. G., D’Ippolito, Giuseppe
Format: Article
Language:English
Subjects:
Abdominal Radiology
Biomarkers
Diagnostic Radiology
Diagnostic systems
Fibrosis
Hepatitis
Histopathology
Imaging
Inflammation
Interventional Radiology
Liver
Mapping
Medical imaging
Medicine
Medicine & Public Health
Neuroradiology
Radiology
Statistical analysis
Ultrasound
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Summary:Purpose There is an unmet clinical need for non-invasive imaging biomarkers that could replace liver biopsy in the management of patients with autoimmune hepatitis (AIH). In this study, we sought to evaluate the diagnostic accuracy of a simple uncorrected, non-contrast T1 mapping for detecting fibrosis and inflammation in AIH patients using histopathology as a reference standard. Material and methods Over 3 years, 33 patients with AIH were prospectively studied using a multiparametric liver MRI protocol which included T1 mapping. Biopsies were performed up to 3 months before imaging, and a standardized histopathological score for fibrosis (F0–F4) and inflammatory activity (PPA0–4) was used as a reference. Statistical analysis included independent t test, Mann–Whitney U-test, and ROC (receiver operating characteristic) analysis. Results T1 mapping values were significantly higher in patients with advanced fibrosis (F0–2 vs. F3–4; p  
ISSN:1826-6983
0033-8362
1826-6983
DOI:10.1007/s11547-024-01863-2