Predictors of prolonged supratherapeutic serum lithium concentrations: a retrospective chart review

The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup suggests hemodialysis in severe lithium poisoning if specific criteria are met. One criterion is if the expected time to obtain a lithium concentration 36 h. There are a lack of data regarding which patient characteristics are associated...

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Bibliographic Details
Published in:Clinical toxicology (Philadelphia, Pa.) Pa.), 2024-09, Vol.62 (9), p.550-556
Main Authors: Ahsan, Salman, Illg, Zachary N, Moran, Tim Patrick, Morgan, Brent W, Carpenter, Joseph E
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Lithium - blood
Lithium Compounds - blood
Lithium Compounds - poisoning
Male
Middle Aged
Nomograms
Renal Dialysis
Retrospective Studies
Risk Factors
Time Factors
Citations: Items that this one cites
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Summary:The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup suggests hemodialysis in severe lithium poisoning if specific criteria are met. One criterion is if the expected time to obtain a lithium concentration 36 h. There are a lack of data regarding which patient characteristics are associated with the rate at which patients achieve a lithium concentration 1.2 mEq/L during hospitalization. We excluded patients who received extracorporeal treatment before 36 h elapsed from time of initial lithium concentration >1.2 mEq/L. The primary analysis consisted of a Cox regression and a secondary analysis evaluated the nomogram method described by Buckley and colleagues for predicting prolonged supratherapeutic lithium concentration. One hundred and one patients were included in the study. The median time to reach a lithium concentration
ISSN:1556-3650
1556-9519
1556-9519
DOI:10.1080/15563650.2024.2387654