Circulating vascular endothelial growth factor receptor‐3, a pro‐lymphangiogenic and pro‐angiogenic mediator, is decreased in pre‐eclampsia

Objective To compare circulating levels of vascular endothelial growth factor receptor 3 (VEGFR‐3) in women with pregnancy‐induced hypertension (PIH) and in non‐pregnant (NP) and healthy pregnant (HP) women. Methods We conducted a case–control study including PIH (n = 135), HP (n = 68), and NP (n = ...

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Published in:International journal of gynecology and obstetrics 2025-01, Vol.168 (1), p.210-219
Main Authors: Palei, Ana C., Kaihara, Julyane N. S., Cavalli, Ricardo C., Sandrim, Valeria C.
Format: Article
Language:English
Subjects:
Adult
adverse prenatal outcomes
Biomarkers - blood
Brazil
Case-Control Studies
Female
gestational hypertension
Humans
Hypertension, Pregnancy-Induced - blood
Pre-Eclampsia - blood
Pregnancy
pre‐eclampsia
vascular endothelial growth factor receptor
Vascular Endothelial Growth Factor Receptor-3 - blood
VEGFR‐3
Young Adult
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Summary:Objective To compare circulating levels of vascular endothelial growth factor receptor 3 (VEGFR‐3) in women with pregnancy‐induced hypertension (PIH) and in non‐pregnant (NP) and healthy pregnant (HP) women. Methods We conducted a case–control study including PIH (n = 135), HP (n = 68), and NP (n = 49) women from southeastern Brazil. PIH were diagnosed according to international guidelines, and defined as gestational hypertension (GH, n = 61) or pre‐eclampsia (n = 74). VEGFR‐3 was measured in plasma using ELISA. Results Plasma VEGFR‐3 was increased in HP (1207 pg/mL) compared with NP (133 pg/mL) women; however, PIH (729 pg/mL) patients exhibited lower levels than HP women (both p 
ISSN:0020-7292
1879-3479
1879-3479
DOI:10.1002/ijgo.15838