Trabecular bone score norms in Asian‐Indians and associations with serum 25(OH)D and parathyroid hormone

• Published in: Clinical endocrinology (Oxford) 2024-12, Vol.101 (6), p.614-622
• Main Authors: Mannar, Velmurugan, Vishal, Anand, Saha, Soma, Kalaivani, Mani, Kandasamy, Devasenathipathy, Goswami, Ravinder
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Absorptiometry, Photon; Adult; Bone Density - physiology; Bone mineral density; Calcium (dietary); Cancellous bone; Cancellous Bone - diagnostic imaging; Dietary intake; Female; Fractures; Gender; Hemoglobin; Humans; Male; Middle Aged; Osteopenia; Osteoporosis; Parathyroid hormone; Parathyroid Hormone - blood; PTH; Sex differences; South Asian People; trabecular bone score; Vertebrae; vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Young Adult
• ISSN: 0300-0664; 1365-2265; 1365-2265
• DOI: 10.1111/cen.15122

Objective There is limited information on population‐specific norms of trabecular‐bone‐score (TBS) and its associated factors. Here, we provide norms of TBS in Asian‐Indians and its relationship with serum 25‐hydroxyvitamin D [25(OH)D] and intact‐parathyroid hormone (iPTH). Participants and Measurements TBS, bone‐mineral‐density (BMD), and vertebral‐fractures (VFs) were assessed using dual‐energy X‐ray absorptiometry in 923 healthy Asian‐Indians (aged 20–60 years). Serum 25(OH)D, iPTH, T4/TSH,, glycosylated‐haemoglobin (HbA1c) were measured and associations with TBS assessed using multivariable linear regression. Subjects with BMD Z‐score ≤ −2.0 or ≥2.0 at any sites, VFs, TSH > 10.0 or 11.1 mmol/L or HbA1c > 8.0% were excluded for generating Asian‐Indian norms. Results TBS norms were generated in 744 healthy Asian‐Indians (M:F,389:385). The cut‐offs generated for ‘normal’, ‘partially‐degraded’, and ‘degraded’ TBS were >1.305, 1.204–1.305 and