Efficient Synthesis of Cyanohydrin Esters: P(NMe2)3 Mediated Direct Deoxygenation of Acyl Cyanides with Carboxylic Acids

An efficient synthesis of cyanohydrin esters via a P­(NMe2)3 mediated direct deoxygenation process has been exploited, circumventing the release or transformation of the CN anion during the reaction. This approach possesses a broad scope and acts as a powerful supplement for the construction of div...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-08, Vol.89 (16), p.11777-11782
Main Authors: Huang, Yuanyuan, Wang, Nan, Wang, Mengke, Zi, You, Huang, Weichun
Format: Article
Language:English
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Summary:An efficient synthesis of cyanohydrin esters via a P­(NMe2)3 mediated direct deoxygenation process has been exploited, circumventing the release or transformation of the CN anion during the reaction. This approach possesses a broad scope and acts as a powerful supplement for the construction of diverse cyanohydrin esters. It offers advantages such as mild conditions, straightforward operations, and excellent scalability, affirming the feasibility and versatility of this approach and highlighting its potential in practical synthesis.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c01081