Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement

• Published in: GeroScience 2024-08
• Main Authors: Ladányi, Zsuzsanna, Bálint, Tímea, Fábián, Alexandra, Ujvári, Adrienn, Turschl, Tímea Katalin, Nagy, Dávid, Straub, Éva, Fejér, Csaba, Zima, Endre, Apor, Astrid, Nagy, Anikó Ilona, Szigethi, Tímea, Papp, Roland, Molnár, Levente, Kovács, Attila, Ruppert, Mihály, Lakatos, Bálint Károly, Merkely, Béla
• Format: Article
• Language: English
• ISSN: 2509-2723; 2509-2723
• DOI: 10.1007/s11357-024-01302-0

Aortic stenosis has become the most prevalent valvular disease with increasing life expectancy and the ageing of the population, representing a significant clinical burden for health care providers. Its treatment has been revolutionized by transcatheter aortic valve replacement (TAVR) as a safe and minimally invasive option for elderly patients. Left ventricular (LV) functional measurement is of particular importance before TAVR, however, increased afterload significantly influences the conventional echocardiographic parameters. Non-invasive myocardial work examines myocardial deformation in the context of instantaneous LV pressure, thus, it might be a more reliable measure of LV function. Accordingly, we aimed to study non-invasive myocardial work and its relationship with functional outcome following TAVR.We enrolled 90 TAVR candidates (80 [75-84] years; 44% female). Using echocardiography, we quantified ejection fraction (EF), global longitudinal strain (GLS), global myocardial work index (GWI) and global constructive work (GCW) before and 12 months after the procedure. Serum NT-proBNP levels were also measured. EF did not change (52.6 ± 13.1 vs. 54.2 ± 10.5%; p = 0.199), while GLS increased (-13.5 ± 4.6 vs. -15.2 ± 3.8%; p