Paradoxical sleep deprivation and restriction promote castration-like effects and local inflammatory responses in male gerbil prostate

• Published in: Journal of biosciences 2024-07, Vol.49 (3), p.77, Article 77
• Main Authors: Fochi, Ricardo A, Ruiz, Thalles F R, Jesus, Mariana M, Azevedo, Lucas R, Falleiros-Júnior, Luiz R, Campos, Silvana G P, Góes, Rejane M, Oliani, Sonia M, Vilamaior, Patricia S L, Taboga, Sebastião R
• Format: Article
• Language: English
• Subjects: Androgen receptors; Androgens; Androgens - metabolism; Animals; Biomedical and Life Sciences; Biomedicine; Castration; Cell Biology; Corticosterone; Corticosterone - blood; Cytokines; Cytokines - metabolism; Epithelium; Gerbillinae; Glucocorticoid receptors; Glucocorticoids; Homeostasis; Hormones; Inflammation; Inflammation - metabolism; Inflammation - pathology; Inflammatory response; Interleukin 1 receptors; Interleukins; Life Sciences; Male; Metabolism; Microbiology; Plant Sciences; Prostate; Prostate - metabolism; Prostate - pathology; Receptors; Receptors, Androgen - genetics; Receptors, Androgen - metabolism; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Recovery; REM sleep; Sex hormones; Sleep; Sleep deprivation; Sleep Deprivation - metabolism; Sleep Deprivation - pathology; Stroma; Testosterone; Testosterone - blood; Tumor necrosis factor-α; Zoology
• ISSN: 0973-7138; 0250-5991; 0973-7138
• DOI: 10.1007/s12038-024-00450-x

Paradoxical sleep deprivation (PSD) presents different effects on metabolism and neurological functions. In addition, over long duration, sleep restriction (SR) can promote permanent changes. The prostate is an endocrine-dependent organ with homeostatic regulation directly related to hormone levels. Our study proposed to demonstrate the experimental prostatic effects of PSD (96 h), PSD with recovery (PSR – 96/96 h), and sleep restriction (SR – 30 PSD cycles/recovery). PSD and SR promoted decrease in serum testosterone and significant increase in serum and intraprostatic corticosterone. In agreement, androgen receptors (AR) were less expressed and glucocorticoid receptors (GR) were enhanced in PSR and SR. Thus, the prostate, especially under SR, demonstrates a castration-like effect due to loss of responsiveness and sensitization by androgens. SR triggered an important inflammatory response through enhancement of serum and intraprostatic pro- (IL-1α, IL-6, TNF-α) and anti-inflammatory (IL-10) cytokines. Furthermore, the respective receptors of anti-inflammatory cytokines (IL-1RI and TNF-R) were highly expressed in the prostatic epithelium and stroma. PSR can partially restore prostate homeostasis, as it restores testosterone and the prostate proliferation index, in addition to promoting balance in the inflammatory response that is considered protective. PSD and SR are key factors in the endocrine axis that coordinate prostatic homeostasis, and significant changes in these factors have consequences on prostate functionality. Graphical abstract