Correlation between corneal endothelial layer features and age-related macular degeneration severity

Purpose This study aimed to investigate the relationship between corneal endothelial layer features and the severity of age-related macular degeneration (AMD). Methods The study included 119 patients, with 47 females and 72 males. Patients were categorized into four groups based on the AREDS grading...

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Bibliographic Details
Published in:International ophthalmology 2024-08, Vol.44 (1), p.345, Article 345
Main Authors: Ozturk, Emrah, Cankaya, Cem, Yildizli, Yakup
Format: Article
Language:English
Subjects:
Age
Age related diseases
Aged
Aged, 80 and over
Cell Count
Cell density
Coefficient of variation
Cornea
Correlation
Endothelial cells
Endothelium, Corneal - pathology
Eye diseases
Female
Hexagonal cells
Humans
Macular degeneration
Macular Degeneration - diagnosis
Macular Degeneration - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Original Paper
Retrospective Studies
Severity of Illness Index
Thickness measurement
Tomography, Optical Coherence - methods
Visual Acuity
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Summary:Purpose This study aimed to investigate the relationship between corneal endothelial layer features and the severity of age-related macular degeneration (AMD). Methods The study included 119 patients, with 47 females and 72 males. Patients were categorized into four groups based on the AREDS grading system: no AMD (group 1), mild AMD (group 2), moderate AMD (group 3), and advanced AMD (group 4). Only the right eye of patients with both eyes suitable for the study was included. Corneal endothelial cell density (CD), coefficient of variation (CoV), hexagonal cell ratio (HEX), and central corneal thickness (CCT) were measured using specular microscopy (Konan Medical Inc., Nishinomiya, Japan). Results Group 1 had 40 patients, group 2 had 27 patients, and groups 3 and 4 had 26 patients each. Significant differences were observed between the mean endothelial CD, CoV, and HEX values among the groups, while no significant difference was found in CCT values ( p  = 0.049, p  = 0.002, p  = 0.004, and p  = 0.883, respectively). A mild negative correlation was observed between AMD severity and CD and HEX values, while a mild positive correlation was found between AMD severity and CoV. Conclusion Increasing severity of AMD may negatively impact corneal endothelial layer values.
ISSN:1573-2630
0165-5701
1573-2630
DOI:10.1007/s10792-024-03271-x