Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach

The global demand for an enhanced quality of life and extended lifespan has driven significant advancements in tissue engineering and regenerative medicine. These fields utilize a range of interdisciplinary theories and techniques to repair structurally impaired or damaged tissues and organs, as wel...

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Bibliographic Details
Published in:Biofabrication 2024-08, Vol.16 (4), p.42005
Main Authors: Khan, Muhammad Umar Aslam, Aslam, Muhammad Azhar, Abdullah, Mohd Faizal Bin, Gul, Hilal, Stojanović, Goran M, Abdal-Hay, Abdalla, Hasan, Anwarul
Format: Article
Language:English
Subjects:
Animals
Drug Delivery Systems - instrumentation
Humans
Microinjections - instrumentation
microneedles
Needles
Regenerative Medicine
regenerative medicines
Tissue Engineering
transdermal drug delivery
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Summary:The global demand for an enhanced quality of life and extended lifespan has driven significant advancements in tissue engineering and regenerative medicine. These fields utilize a range of interdisciplinary theories and techniques to repair structurally impaired or damaged tissues and organs, as well as restore their normal functions. Nevertheless, the clinical efficacy of medications, materials, and potent cells used at the laboratory level is always constrained by technological limitations. A novel platform known as adaptable microneedles has been developed to address the abovementioned issues. These microneedles offer a solution for the localized distribution of various cargos while minimizing invasiveness. Microneedles provide favorable patient compliance in clinical settings due to their effective administration and ability to provide a painless and convenient process. In this review article, we summarized the most recent development of microneedles, and we started by classifying various microneedle systems, advantages, and fundamental properties. Subsequently, it provides a comprehensive overview of different types of microneedles, the material used to fabricate microneedles, the fundamental properties of ideal microneedles, and their applications in tissue engineering and regenerative medicine, primarily focusing on preserving and restoring impaired tissues and organs. The limitations and perspectives have been discussed by concluding their future therapeutic applications in tissue engineering and regenerative medicines.
ISSN:1758-5082
1758-5090
1758-5090
DOI:10.1088/1758-5090/ad6d90