A causal effect study of cortical morphology and related covariate networks in classical trigeminal neuralgia patients

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-08, Vol.34 (8)
• Main Authors: Zhang, Pengfei, Wan, Xinyue, Jiang, Jingqi, Liu, Yang, Wang, Danyang, Ai, Kai, Liu, Guangyao, Zhang, Xinding, Zhang, Jing
• Format: Article
• Language: English
• Subjects: Adult; Aged; Brain Mapping; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Female; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - pathology; Trigeminal Neuralgia - diagnostic imaging; Trigeminal Neuralgia - pathology; Trigeminal Neuralgia - physiopathology
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhae337

Abstract Structural covariance networks and causal effects within can provide critical information on gray matter reorganization and disease-related hierarchical changes. Based on the T1WI data of 43 classical trigeminal neuralgia patients and 45 controls, we constructed morphological similarity networks of cortical thickness, sulcal depth, fractal dimension, and gyrification index. Moreover, causal structural covariance network analyses were conducted in regions with morphological abnormalities or altered nodal properties, respectively. We found that patients showed reduced sulcal depth, gyrification index, and fractal dimension, especially in the salience network and the default mode network. Additionally, the integration of the fractal dimension and sulcal depth networks was significantly reduced, accompanied by decreased nodal efficiency of the bilateral temporal poles, and right pericalcarine cortex within the sulcal depth network. Negative causal effects existed from the left insula to the right caudal anterior cingulate cortex in the gyrification index map, also from bilateral temporal poles to right pericalcarine cortex within the sulcal depth network. Collectively, patients exhibited impaired integrity of the covariance networks in addition to the abnormal gray matter morphology in the salience network and default mode network. Furthermore, the patients may experience progressive impairment in the salience network and from the limbic system to the sensory system in network topology, respectively.