Relationship between Circadian System Status, Child-Pugh Score, and Clinical Outcome in Cirrhotic Patients on Waiting Lists for Liver Transplantation

Many patients suffering from liver cirrhosis are eventually added to waiting lists for liver transplantation whose priority is established based on scales such as the Child-Pugh score. However, two marker rhythms of the circadian system, motor activity and distal temperature, are not evaluated. To d...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2024-08, Vol.13 (15), p.4529
Main Authors: Martínez-Alarcón, Laura, Martínez-Nicolás, Antonio, Jover-Aguilar, Marta, López-López, Víctor, Alconchel-Gago, Felipe, Ríos, Antonio, Madrid, Juan Antonio, de Los Ángeles Rol, María, Ramírez, Pablo, Ramis, Guillermo
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Blood
Blood platelets
Body mass index
Care and treatment
Circadian rhythms
Development and progression
Diagnosis
Enzymes
Health aspects
Hematology
Hemoglobin
Hormones
Hospitals
Informed consent
Liver
Liver cirrhosis
Liver diseases
Liver transplants
Malnutrition
Medical waiting lists
Melatonin
Microelectromechanical systems
Patients
Quality of life
Rhythm
Skin
Sleep disorders
Transplantation
Variables
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many patients suffering from liver cirrhosis are eventually added to waiting lists for liver transplantation whose priority is established based on scales such as the Child-Pugh score. However, two marker rhythms of the circadian system, motor activity and distal temperature, are not evaluated. To determine the relationship between the functional status of the circadian system and the Child-Pugh scale in patients awaiting liver transplantation, distal temperature, motor activity, and light exposure rhythms were monitored for a full week using a wrist device (Kronowise 6.0) in 63 patients (17 women, 46 men) aged between 20 and 76 years. Circadian parameters (amplitude, regularity, and fragmentation) of motor activity rhythms, distal temperature, and light exposure worsen in close association with liver disease severity as assessed by using the Child-Pugh score. Likewise, the worsening of rhythmic parameters and liver disease is associated with a deterioration in the markers of the red series: count, hemoglobin, and hematocrit. These results indicate the utility of ambulatory monitoring of marker rhythms to complement the clinical information provided by the Child-Pugh scale and to help establish nutrition, physical exercise, and sleep guidelines that promote better survival and quality of life in these patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13154529